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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3llt ANP Protein serine/threonine kinase-1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3llt ANPProtein serine/threonine kinase-1 / 0.969
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.817
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.814
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.783
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.775
3oro AGSSerine/threonine protein kinase / 0.774
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.769
3c4w ATPRhodopsin kinase / 0.734
2pul ACPMethylthioribose kinase 2.7.1.100 0.725
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.725
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.723
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.723
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.723
5dt4 ATPAurora kinase A 2.7.11.1 0.722
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.717
4ceg ADPAurora kinase A 2.7.11.1 0.716
3c4z ADPRhodopsin kinase / 0.711
4jrn ANPRhoptry kinase family protein / 0.711
3t8o ATPRhodopsin kinase / 0.706
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.704
4ysj ADPCalmodulin-like domain protein kinase / 0.701
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.698
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.697
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.696
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.695
1mq4 ADPAurora kinase A 2.7.11.1 0.694
3c50 ADPRhodopsin kinase / 0.693
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.691
4bn1 ADPAurora kinase A 2.7.11.1 0.691
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.690
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
2dwb ANPAurora kinase A 2.7.11.1 0.690
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.690
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.689
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.688
4gyi ADPUncharacterized protein / 0.688
2pui ADPMethylthioribose kinase 2.7.1.100 0.687
3ort AGSSerine/threonine protein kinase / 0.687
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.687
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.684
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
3nie ANPMitogen-activated protein kinase / 0.683
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.680
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.680
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.679
3orm AGSSerine/threonine protein kinase / 0.678
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.678
3rv4 ADPBiotin carboxylase 6.3.4.14 0.677
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.677
2pun ACPMethylthioribose kinase 2.7.1.100 0.675
4o4e ATPKinase / 0.675
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1ol6 ATPAurora kinase A 2.7.11.1 0.672
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4lv8 ADPRhoptry protein 5 C / 0.671
5dt3 ATPAurora kinase A 2.7.11.1 0.671
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.669
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.668
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.668
3qc9 ADPRhodopsin kinase / 0.668
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.667
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.667
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.666
5byl GCPBifunctional AAC/APH 2.3.1 0.666
2pyw ADPMethylthioribose kinase 2.7.1.100 0.665
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.665
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.664
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.661
2py3 ACPFibroblast growth factor receptor 2 / 0.661
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.661
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.659
3a8w ATPProtein kinase C iota type 2.7.11.13 0.659
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.659
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.658
4o4f ATPKinase / 0.658
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.657
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.657
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.657
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.657
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.657
1m0w ANPGlutathione synthetase 6.3.2.3 0.656
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.655
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.655
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.654
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.654
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.654
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.654
3cly ACPFibroblast growth factor receptor 2 / 0.653
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.652
2yaa ATPDeath-associated protein kinase 2 / 0.652
4o4d ATPKinase / 0.652
5dn3 ATPAurora kinase A 2.7.11.1 0.652
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
2j5x GSPADP-ribosylation factor 6 / 0.651
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.651
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.650
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.650
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.650
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
4xlv ACPInsulin receptor 2.7.10.1 0.650