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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zkj ADP [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 1.011
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.984
3a0t ADPSensor histidine kinase / 0.879
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.835
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.832
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.828
4prx ADPDNA gyrase subunit B / 0.791
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.787
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.777
1z5a ADPType 2 DNA topoisomerase 6 subunit B / 0.758
4prv ADPDNA gyrase subunit B / 0.756
3sl2 ATPSensor histidine kinase WalK / 0.755
1nhh ANPDNA mismatch repair protein MutL / 0.753
1th8 ADPAnti-sigma F factor / 0.744
4xcl AGSHeat shock cognate 90 kDa protein / 0.740
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.734
3t2s AGSHeat shock protein HSP 90-alpha / 0.732
1thn ADPAnti-sigma F factor / 0.729
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.726
4ipe ANPTNF receptor-associated protein 1 / 0.725
4xcj ADPHeat shock cognate 90 kDa protein / 0.725
2c2a ADPSensor histidine kinase / 0.721
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 0.717
4wud ANPDNA gyrase subunit B / 0.714
4ivg ANPTNF receptor-associated protein 1 / 0.712
2ior ADPChaperone protein HtpG / 0.696
4wuc ANPDNA gyrase subunit B / 0.696
4xc0 ACPHeat shock cognate 90 kDa protein / 0.694
2xcm ADPCytosolic heat shock protein 90 / 0.685
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.679
4bix ADPSensor histidine kinase CpxA / 0.678
1yt0 ADPEndoplasmin / 0.677
3t1k ANPHeat shock protein HSP 90-alpha / 0.677
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.677
1y4s ADPChaperone protein HtpG / 0.668
3t0z ATPHeat shock protein HSP 90-alpha / 0.662
2xk2 ADPHeat shock protein HSP 90-alpha / 0.659
1l0o ADPAnti-sigma F factor / 0.658
3dge ADPSensor histidine kinase / 0.658
1byq ADPHeat shock protein HSP 90-alpha / 0.656
1til ATPAnti-sigma F factor / 0.653
4biz ADPSensor histidine kinase CpxA / 0.653
1g4p FQPThiamine-phosphate synthase / 0.652
4r3a ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.652
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.651
3t10 ACPHeat shock protein HSP 90-alpha / 0.651
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.650