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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q66 ATP Poly(A) polymerase 2.7.7.19

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2q66 ATPPoly(A) polymerase 2.7.7.19 0.968
2ikf UTPPoly(A) polymerase, putative / 0.823
4rwn APC2'-5'-oligoadenylate synthase 1 2.7.7.84 0.803
4xj4 3ATCyclic GMP-AMP synthase / 0.798
2b51 UTPRNA editing complex protein MP57 / 0.768
4k97 ATPCyclic GMP-AMP synthase / 0.766
3sup DCPDNA-directed DNA polymerase / 0.755
4u03 GTPCyclic GMP-AMP synthase / 0.753
4m42 ATPDNA-directed DNA polymerase / 0.749
1r8b ATPCCA-adding enzyme 2.7.7.72 0.745
5a2w AGSMitochondrial poly(A) polymerase / 0.740
4fj5 DTPDNA-directed DNA polymerase / 0.736
3hiy UTPUncharacterized protein / 0.735
2b56 UTPRNA editing complex protein MP57 / 0.733
4dfk 0L5DNA polymerase I, thermostable 2.7.7.7 0.730
1r89 CTPCCA-adding enzyme 2.7.7.72 0.728
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.724
4dtj TTPDNA-directed DNA polymerase / 0.724
4fk4 DGTDNA-directed DNA polymerase / 0.723
4u0m GTPCyclic GMP-AMP synthase / 0.722
3ne6 DCPDNA-directed DNA polymerase / 0.721
3lzj CTPDNA-directed DNA polymerase / 0.718
4khy TTPDNA-directed DNA polymerase / 0.716
1r8c UTPCCA-adding enzyme 2.7.7.72 0.711
4lt6 3ATPoly(A) polymerase gamma 2.7.7.19 0.709
2q0c CTPPoly(A) polymerase, putative / 0.708
4xj3 GTPCyclic GMP-AMP synthase / 0.708
2q0d ATPPoly(A) polymerase, putative / 0.704
4fjm DCPDNA-directed DNA polymerase / 0.704
3q23 G2PVirion DNA-directed RNA polymerase / 0.703
4fjh DGTDNA-directed DNA polymerase / 0.702
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.700
3au2 DGTDNA polymerase beta family (X family) / 0.697
5a30 AGSMitochondrial poly(A) polymerase / 0.694
4dtp DGTDNA-directed DNA polymerase / 0.692
4ptf DCPDNA polymerase epsilon catalytic subunit A 2.7.7.7 0.691
4dto DCPDNA-directed DNA polymerase / 0.690
4fjj TTPDNA-directed DNA polymerase / 0.690
3ova APCCCA-adding enzyme 2.7.7.72 0.688
4m3t ATPDNA-directed DNA polymerase / 0.687
3g6x DGTDNA polymerase iota 2.7.7.7 0.685
1cjv DADAdenylate cyclase type 2 / 0.679
1cjv DADAdenylate cyclase type 5 / 0.679
2zh6 ATPCCA-adding enzyme 2.7.7.72 0.678
4fvq ATPTyrosine-protein kinase JAK2 / 0.676
1qtm TTPDNA polymerase I, thermostable 2.7.7.7 0.674
4dtx TTPDNA-directed DNA polymerase / 0.673
4fhp UTPTerminal uridylyltransferase cid1 / 0.671
4m3x ATPDNA-directed DNA polymerase / 0.670
4at8 ATPInterleukin enhancer-binding factor 2 / 0.669
3wbz ATPtRNA(His) guanylyltransferase {ECO:0000256|PIRNR:PIRNR028980} / 0.668
3q5d GDPAtlastin-1 3.6.5 0.663
1fa0 3ATPoly(A) polymerase 2.7.7.19 0.658
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.656
4tv9 GTPTubulin alpha-1B chain / 0.656
4fjl DGTDNA-directed DNA polymerase / 0.655
4txz G2PCyclic GMP-AMP synthase / 0.653
4nxv GDPMitochondrial dynamics protein MID51 / 0.652
4ihj GTPTubulin alpha-1B chain / 0.651
1qsy DDSDNA polymerase I, thermostable 2.7.7.7 0.650
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650