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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2onm NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.115
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.904
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.881
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.876
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.869
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.864
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.862
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.861
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.853
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.850
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.841
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.837
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.823
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.797
4i9b NADPutative betaine aldehyde dehyrogenase / 0.791
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.789
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.788
4i8p NADAminoaldehyde dehydrogenase 1 / 0.787
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.780
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.778
4i8q NADPutative betaine aldehyde dehyrogenase / 0.763
4pz2 NADAldehyde dehydrogenase 2-6 / 0.759
4f3x NADPutative aldehyde dehydrogenase / 0.756
3iwj NADAminoaldehyde dehydrogenase / 0.741
4pxl NADAldehyde dehydrogenase3 / 0.741
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.740
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.740
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.739
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.738
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.738
3b4w NADAldehyde dehydrogenase family protein / 0.737
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.736
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.736
4pt0 NADAldehyde dehydrogenase / 0.731
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.729
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.725
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.722
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.722
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.721
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.720
4i3v NADAldehyde dehydrogenase (NAD+) / 0.720
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.718
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.718
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.717
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.713
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.713
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.712
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.708
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.706
5eyu NADBetaine-aldehyde dehydrogenase / 0.705
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.704
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.700
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.698
5ez4 NADBetaine-aldehyde dehydrogenase / 0.698
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.695
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.694
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.693
2jg7 NADAntiquitin / 0.692
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.689
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.688
5dib NADBetaine-aldehyde dehydrogenase / 0.688
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.686
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.680
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.680
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.679
4i3w NADAldehyde dehydrogenase (NAD+) / 0.677
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.675
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.674
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.674
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.674
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.673
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.672
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.672
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.668
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.664
4nmj NAPAldehyde dehydrogenase / 0.662
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.653
4h73 NDPAldehyde dehydrogenase / 0.651
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.650