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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j6l NAI Alpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 1.141
2jg7 NADAntiquitin / 1.067
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.943
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.941
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.937
3b4w NADAldehyde dehydrogenase family protein / 0.927
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.925
4i8p NADAminoaldehyde dehydrogenase 1 / 0.923
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.915
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.911
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.903
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.900
4pz2 NADAldehyde dehydrogenase 2-6 / 0.884
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.880
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.875
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.872
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.866
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.864
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.863
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.855
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.849
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.846
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.844
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.843
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.842
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.831
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.826
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.823
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.815
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.814
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.811
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.804
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.801
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.800
4i8q NADPutative betaine aldehyde dehyrogenase / 0.798
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.791
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.786
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.776
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.773
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.769
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.769
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.766
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.761
4i3w NADAldehyde dehydrogenase (NAD+) / 0.761
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.756
3haz NADBifunctional protein PutA / 0.752
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.751
4i3v NADAldehyde dehydrogenase (NAD+) / 0.749
4c3s NADAldehyde Dehydrogenase / 0.742
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.731
4pxl NADAldehyde dehydrogenase3 / 0.727
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.723
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.721
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.718
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.713
4pt0 NADAldehyde dehydrogenase / 0.712
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.710
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.707
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.705
4f3x NADPutative aldehyde dehydrogenase / 0.701
3iwj NADAminoaldehyde dehydrogenase / 0.699
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.699
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.699
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.698
4i9b NADPutative betaine aldehyde dehyrogenase / 0.696
1bi9 NADRetinal dehydrogenase 2 / 0.695
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.693
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.692
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.691
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.689
4nmj NAPAldehyde dehydrogenase / 0.684
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.683
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.682
4h73 NDPAldehyde dehydrogenase / 0.679
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.672
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.670