Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j40 NAD 1-pyrroline-5-carboxylate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.268
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 1.243
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.223
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.222
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.201
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.163
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 1.112
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.056
4i8q NADPutative betaine aldehyde dehyrogenase / 1.052
3efv NADPutative succinate-semialdehyde dehydrogenase / 1.043
4pz2 NADAldehyde dehydrogenase 2-6 / 1.026
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.993
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.989
3b4w NADAldehyde dehydrogenase family protein / 0.985
4i8p NADAminoaldehyde dehydrogenase 1 / 0.956
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.940
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.907
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.900
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.897
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.895
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.884
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.880
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.877
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.876
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.867
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.866
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.857
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.853
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.852
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.840
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.825
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.824
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.820
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.817
3haz NADBifunctional protein PutA / 0.801
4i9b NADPutative betaine aldehyde dehyrogenase / 0.800
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.797
4pxl NADAldehyde dehydrogenase3 / 0.795
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.794
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.792
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.791
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.789
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.788
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.787
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.787
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.772
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.768
4nmj NAPAldehyde dehydrogenase / 0.756
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.749
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.749
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.748
2jg7 NADAntiquitin / 0.747
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.747
4nmk NAPAldehyde dehydrogenase / 0.747
4c3s NADAldehyde Dehydrogenase / 0.741
4f3x NADPutative aldehyde dehydrogenase / 0.741
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.737
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.736
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.730
4h73 NDPAldehyde dehydrogenase / 0.729
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.729
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.727
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.714
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.712
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.710
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.708
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.697
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.694
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.687
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.685
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.685
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.684
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.680
1bi9 NADRetinal dehydrogenase 2 / 0.677
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.674
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.671
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.670
4i3w NADAldehyde dehydrogenase (NAD+) / 0.667
3iwj NADAminoaldehyde dehydrogenase / 0.663
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.659
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.658
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.653
4ki0 ANPMaltose/maltodextrin import ATP-binding protein MalK / 0.651