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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j0k 4ST Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.974
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.784
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.772
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.758
1drt PCVClavaminate synthase 1 1.14.11.21 0.744
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.744
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
2oap ANPType II secretion system protein (GspE-2) / 0.744
2zs9 ADPPantothenate kinase 2.7.1.33 0.744
3cwq ADPParA family chromosome partitioning protein / 0.744
3f8p NADNADH oxidase/thioredoxin reductase / 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3u9d ATPActin, alpha skeletal muscle / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
4e5l DBHPolymerase acidic protein / 0.744
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.731
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.719
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.716
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.705
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.690
1byg STUTyrosine-protein kinase CSK / 0.689
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.689
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.688
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.684
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.684
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.680
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.677
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.665
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.663
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.660
4cdg ADPBloom syndrome protein 3.6.4.12 0.660
4nxv GDPMitochondrial dynamics protein MID51 / 0.660
4nxx GDPMitochondrial dynamics protein MID51 / 0.660
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.659
3zew STUEphrin type-B receptor 4 2.7.10.1 0.659
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.657