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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dph NAD Formaldehyde dismutase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dph NADFormaldehyde dismutase / 1.278
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.966
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.859
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.822
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.810
4cpd NADAlcohol dehydrogenase / 0.801
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.794
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.793
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.791
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.788
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.780
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.772
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.771
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.771
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.769
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.767
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.765
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.761
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.760
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.759
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.757
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.756
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.754
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.752
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.751
3jv7 NADSecondary alcohol dehydrogenase / 0.748
2d8a NADL-threonine 3-dehydrogenase / 0.747
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.746
4oaq NDPR-specific carbonyl reductase / 0.746
1u7h NADPutative ornithine cyclodeaminase / 0.743
1f8f NADBenzyl alcohol dehydrogenase / 0.737
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.731
3zw9 NADPeroxisomal bifunctional enzyme 1.1.1.35 0.731
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.730
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.730
1x7d NADPutative ornithine cyclodeaminase / 0.729
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.728
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.725
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.724
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.723
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.721
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
4c4o NADSADH / 0.718
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.716
2voj NADAlanine dehydrogenase 1.4.1.1 0.714
2o4c NADErythronate-4-phosphate dehydrogenase / 0.711
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.708
3wle NAD(R)-specific carbonyl reductase / 0.708
4jk3 NADUncharacterized protein / 0.708
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.707
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.704
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.702
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.699
2vhx NADAlanine dehydrogenase 1.4.1.1 0.699
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.698
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.695
4jji NADAlcohol dehydrogenase class-3 / 0.695
3wsw NADL-lactate dehydrogenase / 0.693
3uko NADAlcohol dehydrogenase class-3 / 0.692
1uxk NADMalate dehydrogenase / 0.689
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.689
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.689
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.688
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.688
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.686
4l0q NADAlcohol dehydrogenase class-3 / 0.685
1pjc NADAlanine dehydrogenase / 0.684
2ejv NADL-threonine 3-dehydrogenase / 0.680
3x2f NAIAdenosylhomocysteinase / 0.675
1yqx NAPSinapyl alcohol dehydrogenase / 0.673
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.672
4j43 NADUncharacterized protein / 0.672
2cdc NAPGlucose 1-dehydrogenase / 0.671
3wie DN4Glucose 1-dehydrogenase / 0.671
1uxj NADMalate dehydrogenase / 0.669
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.667
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.667
1hku NADC-terminal-binding protein 1 1.1.1 0.666
4j49 NADUncharacterized protein / 0.666
4j49 NAIUncharacterized protein / 0.665
3ggo NAIPrephenate dehydrogenase / 0.664
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.664
4xrg NADHomospermidine synthase 2.5.1.44 0.664
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.663
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.662
1c1d NAIPhenylalanine dehydrogenase / 0.661
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
1qmg APXKetol-acid reductoisomerase, chloroplastic 1.1.1.86 0.661
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.661
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.660
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.660
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.659
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.659
1ie3 NADMalate dehydrogenase / 0.658
3d64 NADAdenosylhomocysteinase / 0.658
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.657
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
4xqc NADHomospermidine synthase 2.5.1.44 0.656
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.655
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.654
1ib6 NADMalate dehydrogenase / 0.653
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
3f3s NADLambda-crystallin homolog / 0.652
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.652
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.651
3ggp NADPrephenate dehydrogenase / 0.651
3kb6 NADD-lactate dehydrogenase / 0.651
1pzh NADLactate dehydrogenase / 0.650
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.650
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.650