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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cgp CMP cAMP-activated global transcriptional regulator CRP

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cgp CMPcAMP-activated global transcriptional regulator CRP / 0.986
4hzf CMPcAMP-activated global transcriptional regulator CRP / 0.921
4i02 CMPcAMP-activated global transcriptional regulator CRP / 0.918
3rou CMPcAMP-activated global transcriptional regulator CRP / 0.913
4i0b CMPcAMP-activated global transcriptional regulator CRP / 0.901
4ft8 CMPcAMP-activated global transcriptional regulator CRP / 0.885
4i0a CMPcAMP-activated global transcriptional regulator CRP / 0.869
4i01 CMPcAMP-activated global transcriptional regulator CRP / 0.865
3ryp CMPcAMP-activated global transcriptional regulator CRP / 0.864
4i09 CMPcAMP-activated global transcriptional regulator CRP / 0.864
3n4m CMPcAMP-activated global transcriptional regulator CRP / 0.858
1zrd CMPcAMP-activated global transcriptional regulator CRP / 0.852
2oz6 CMPCyclic AMP receptor-like protein / 0.851
3ryr CMPcAMP-activated global transcriptional regulator CRP / 0.851
1i5z CMPcAMP-activated global transcriptional regulator CRP / 0.849
1i6x CMPcAMP-activated global transcriptional regulator CRP / 0.848
3qop CMPcAMP-activated global transcriptional regulator CRP / 0.846
3kcc CMPcAMP-activated global transcriptional regulator CRP / 0.838
3rpq CMPcAMP-activated global transcriptional regulator CRP / 0.833
1g6n CMPcAMP-activated global transcriptional regulator CRP / 0.832
4qx5 CMPcGMP-dependent protein kinase 1 2.7.11.12 0.826
1hw5 CMPcAMP-activated global transcriptional regulator CRP / 0.806
2ptm CMPHyperpolarization-activated (Ih) channel / 0.805
4r8h SP1cAMP-activated global transcriptional regulator CRP / 0.796
1vp6 CMPCyclic nucleotide-gated potassium channel mll3241 / 0.793
4ku7 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.786
3u0z CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / 0.785
2gzw CMPcAMP-activated global transcriptional regulator CRP / 0.779
4hbn CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.765
3u10 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.764
1q43 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.758
1rgs CMPcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.758
5c6c CMPcGMP-dependent protein kinase 2 2.7.11.12 0.758
4d7t CMPUncharacterized protein / 0.756
1q5o CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.755
1zrc CMPcAMP-activated global transcriptional regulator CRP / 0.753
3rdi CMPcAMP-activated global transcriptional regulator CRP / 0.753
3bpz CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.750
3u11 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.748
3cl1 PCGCyclic nucleotide-gated potassium channel mll3241 / 0.746
3ocp CMPcGMP-dependent protein kinase 1 2.7.11.12 0.741
1cx4 CMPcAMP-dependent protein kinase type II-beta regulatory subunit / 0.740
1q3e PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.731
3i59 N6RCRP-like cAMP-activated global transcriptional regulator / 0.729
4ev0 CMPCyclic AMP receptor protein / 0.728
3otf CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.727
5c8w PCGcGMP-dependent protein kinase 2 2.7.11.12 0.726
3ogj CMPcGMP-dependent protein kinase 1 2.7.11.12 0.722
4jva 1ORcAMP-dependent protein kinase type II-beta regulatory subunit / 0.719
1ne4 RP1cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.713
1cgp CMPcAMP-activated global transcriptional regulator CRP / 0.712
3r6s CMPCRP-like cAMP-activated global transcriptional regulator / 0.711
4z07 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.707
4jv4 1ORcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.706
3of1 CMPcAMP-dependent protein kinase regulatory subunit / 0.705
3shr CMPcGMP-dependent protein kinase 1 2.7.11.12 0.704
4mgk CMPRap guanine nucleotide exchange factor 4 / 0.702
3od0 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.701
3i59 N6SCRP-like cAMP-activated global transcriptional regulator / 0.694
1ne6 SP1cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.693
3plq RP2cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.689
4d7s PCGUncharacterized protein / 0.684
4hr2 ADPNucleoside diphosphate kinase / 0.684
4n9i PCGCatabolite expression activator / 0.684
1rl3 PCGcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.679
2k0g CMPCyclic nucleotide-gated potassium channel mll3241 / 0.668
4x3l MTARNA 2'-O ribose methyltransferase / 0.664
3mzh CMPCRP-like cAMP-activated global transcriptional regulator / 0.659
2c2a ADPSensor histidine kinase / 0.656
4kg1 PCGDiguanylate cyclase / 0.656
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.656
5ahw CMPUniversal stress protein family protein, putative / 0.655
3bbd SAHRibosomal RNA small subunit methyltransferase Nep1 2.1.1 0.654