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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cci ATP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.924
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.770
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.766
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.761
1mq4 ADPAurora kinase A 2.7.11.1 0.754
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.746
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.744
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.738
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.737
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.735
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.734
2wtk ANPSTE20-related kinase adapter protein alpha / 0.733
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.732
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.732
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.730
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.728
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.727
4dee ADPAurora kinase A 2.7.11.1 0.725
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.719
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.718
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.716
4ceg ADPAurora kinase A 2.7.11.1 0.716
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.714
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.713
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.712
4c3r ACPAurora kinase A 2.7.11.1 0.711
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.710
4q5h ANPProtein kinase OspG 2.7 0.709
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.708
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.707
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.706
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.703
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.703
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.702
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
5drd ATPAurora kinase A 2.7.11.1 0.697
4o0w ADNAurora kinase A 2.7.11.1 0.696
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.695
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.694
2pup ADPMethylthioribose kinase 2.7.1.100 0.694
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.692
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.690
3cly ACPFibroblast growth factor receptor 2 / 0.688
2pyw ADPMethylthioribose kinase 2.7.1.100 0.685
5dnr ATPAurora kinase A 2.7.11.1 0.685
1ol5 ADPAurora kinase A 2.7.11.1 0.684
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.683
5dos ATPAurora kinase A 2.7.11.1 0.683
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.682
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.681
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.681
3bu5 ATPInsulin receptor 2.7.10.1 0.681
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.681
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
3b2t M33Fibroblast growth factor receptor 2 / 0.679
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.679
5dr2 ATPAurora kinase A 2.7.11.1 0.679
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.678
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.678
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.678
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.676
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.675
5dt4 ATPAurora kinase A 2.7.11.1 0.675
4o4e ATPKinase / 0.674
4o4f ATPKinase / 0.674
5dn3 ATPAurora kinase A 2.7.11.1 0.674
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.673
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
3c4w ATPRhodopsin kinase / 0.672
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.672
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.672
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.671
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.671
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.671
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.669
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
4qny ANPMitogen activated protein kinase, putative / 0.669
1i44 ACPInsulin receptor 2.7.10.1 0.668
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.668
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.668
4ysj ADPCalmodulin-like domain protein kinase / 0.668
5l8j ADPAurora kinase A 2.7.11.1 0.668
2wqe ADPAurora kinase A 2.7.11.1 0.667
2pml ANPUncharacterized protein / 0.666
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.666
4n57 ADPAPH(2'')-Id / 0.666
4o0u ADNAurora kinase A 2.7.11.1 0.666
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.666
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.665
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.665
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.665
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.664
5l8l ADPAurora kinase A 2.7.11.1 0.663
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.662
2dwb ANPAurora kinase A 2.7.11.1 0.661
4xlv ACPInsulin receptor 2.7.10.1 0.661
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.660
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.659
1ol6 ATPAurora kinase A 2.7.11.1 0.658
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.658
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.658
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.658
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.657
3ort AGSSerine/threonine protein kinase / 0.657
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.657
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1rfu ADPPyridoxal kinase 2.7.1.35 0.656
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.656
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.656
3ork AGSSerine/threonine protein kinase / 0.656
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.655
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.655
3qc9 ADPRhodopsin kinase / 0.654
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
4o0s ADNAurora kinase A 2.7.11.1 0.654
4o4d ATPKinase / 0.654
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.653
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.652
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.652
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.651
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.651
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.651
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.651
4lrz ADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL 2.7 0.651
5ce3 ADPProtein kinase YopO / 0.650