Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a19 ANP Interferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.972
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.744
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.737
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.733
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.732
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.730
2pyw ADPMethylthioribose kinase 2.7.1.100 0.729
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.728
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.720
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.719
3bu5 ATPInsulin receptor 2.7.10.1 0.717
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.715
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.715
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.714
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
4ceg ADPAurora kinase A 2.7.11.1 0.707
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.706
4utd ACPAurora kinase A 2.7.11.1 0.704
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.703
5dn3 ATPAurora kinase A 2.7.11.1 0.700
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.700
2py3 ACPFibroblast growth factor receptor 2 / 0.699
3cly ACPFibroblast growth factor receptor 2 / 0.698
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.696
5dr2 ATPAurora kinase A 2.7.11.1 0.695
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.694
4qny ANPMitogen activated protein kinase, putative / 0.694
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.692
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.691
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.689
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.687
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.687
5dos ATPAurora kinase A 2.7.11.1 0.687
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.686
5iqa GNPBifunctional AAC/APH 2.3.1 0.686
1i44 ACPInsulin receptor 2.7.10.1 0.685
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.685
1cm8 ANPMitogen-activated protein kinase 12 / 0.684
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.684
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.683
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.682
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.682
5iqb GNPBifunctional AAC/APH 2.3.1 0.682
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.681
2dwb ANPAurora kinase A 2.7.11.1 0.680
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.680
2pz5 ACPFibroblast growth factor receptor 2 / 0.680
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.680
5iqe GNPBifunctional AAC/APH 2.3.1 0.680
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.679
3wo1 ADPAlanine--anticapsin ligase / 0.679
4q5h ANPProtein kinase OspG 2.7 0.679
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.677
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.675
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.675
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
2pzp ACPFibroblast growth factor receptor 2 / 0.674
4ork GDPBifunctional AAC/APH 2.3.1 0.674
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.673
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.673
5dt3 ATPAurora kinase A 2.7.11.1 0.673
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.672
4xlv ACPInsulin receptor 2.7.10.1 0.672
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.671
5dnr ATPAurora kinase A 2.7.11.1 0.671
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1mq4 ADPAurora kinase A 2.7.11.1 0.669
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.669
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
5l8l ADPAurora kinase A 2.7.11.1 0.668
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
2olc ADPMethylthioribose kinase 2.7.1.100 0.667
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.667
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.666
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.666
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
3a8w ATPProtein kinase C iota type 2.7.11.13 0.666
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.666
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
3tdw GDPGentamicin resistance protein / 0.665
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4n57 ADPAPH(2'')-Id / 0.665
5l8j ADPAurora kinase A 2.7.11.1 0.665
3q5i ANPProtein kinase, putative / 0.664
4c3r ACPAurora kinase A 2.7.11.1 0.664
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.663
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.663
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.663
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.662
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.661
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.661
4o0w ADNAurora kinase A 2.7.11.1 0.661
5ce3 ADPProtein kinase YopO / 0.661
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2pui ADPMethylthioribose kinase 2.7.1.100 0.660
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.660
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.660
5iqg GDPBifunctional AAC/APH 2.3.1 0.660
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.659
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4dee ADPAurora kinase A 2.7.11.1 0.658
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.658
5iqf GDPBifunctional AAC/APH 2.3.1 0.658
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.656
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.656
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.656
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.655
4o4d ATPKinase / 0.655
5l8k ADPAurora kinase A 2.7.11.1 0.655
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
2pup ADPMethylthioribose kinase 2.7.1.100 0.654
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.654
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.653
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.653
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4gyi ADPUncharacterized protein / 0.653
4j98 ACPFibroblast growth factor receptor 2 / 0.653
2wtk ANPSTE20-related kinase adapter protein alpha / 0.652
4bn1 ADPAurora kinase A 2.7.11.1 0.652
2pun ACPMethylthioribose kinase 2.7.1.100 0.651
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2pul ACPMethylthioribose kinase 2.7.1.100 0.650
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4bix ADPSensor histidine kinase CpxA / 0.650
4dt8 ADNAPH(2'')-Id / 0.650