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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1wnb NAI Gamma-aminobutyraldehyde dehydrogenase 1.2.1.19

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 1.163
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.940
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.877
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.865
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.822
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.802
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.793
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.773
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.763
4pxl NADAldehyde dehydrogenase3 / 0.749
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.746
4f3x NADPutative aldehyde dehydrogenase / 0.743
4pt0 NADAldehyde dehydrogenase / 0.743
5eyu NADBetaine-aldehyde dehydrogenase / 0.742
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.741
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
4i8q NADPutative betaine aldehyde dehyrogenase / 0.718
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.714
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.710
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.709
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.704
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.704
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.701
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.695
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.694
3iwj NADAminoaldehyde dehydrogenase / 0.694
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.693
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.692
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.691
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.689
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.687
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.686
5dib NADBetaine-aldehyde dehydrogenase / 0.683
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.682
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.682
4i3v NADAldehyde dehydrogenase (NAD+) / 0.681
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.678
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.678
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.678
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.677
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.676
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.676
3b4w NADAldehyde dehydrogenase family protein / 0.676
1bi9 NADRetinal dehydrogenase 2 / 0.672
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.671
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.670
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.667
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.667
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.666
4pt3 NDPAldehyde dehydrogenase / 0.666
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.661
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.657
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.656
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.651
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.651
5ez4 NADBetaine-aldehyde dehydrogenase / 0.651
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.650