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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uyk PUX Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uyk PUXHeat shock protein HSP 90-alpha / 0.925
2h55 DZ8Heat shock protein HSP 90-alpha / 0.820
1uy9 PU6Heat shock protein HSP 90-alpha / 0.817
1uy8 PU5Heat shock protein HSP 90-alpha / 0.765
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1nmd ATPMajor actin / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.744
3f8p NADNADH oxidase/thioredoxin reductase / 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.744
1uyh PU0Heat shock protein HSP 90-alpha / 0.728
3qdd 94MHeat shock protein HSP 90-alpha / 0.707
1uy7 PU4Heat shock protein HSP 90-alpha / 0.698
4z1f H71Heat shock protein 75 kDa, mitochondrial / 0.690
3o0i P54Heat shock protein HSP 90-alpha / 0.679
1uyi PUZHeat shock protein HSP 90-alpha / 0.673
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.660
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1yra GDPGPN-loop GTPase PAB0955 / 0.660
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2hs4 ACPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.660
4cdg ADPBloom syndrome protein 3.6.4.12 0.660
4nxx GDPMitochondrial dynamics protein MID51 / 0.660
4o3m ADPBloom syndrome protein 3.6.4.12 0.660