Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tqm ANP RIO-type serine/threonine-protein kinase Rio2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.994
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.876
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.792
2olc ADPMethylthioribose kinase 2.7.1.100 0.757
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.756
2pui ADPMethylthioribose kinase 2.7.1.100 0.754
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.743
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.742
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.741
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.729
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.729
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.725
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.724
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.721
4ceg ADPAurora kinase A 2.7.11.1 0.721
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.720
3bu5 ATPInsulin receptor 2.7.10.1 0.720
2pul ACPMethylthioribose kinase 2.7.1.100 0.719
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.718
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.718
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.716
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.715
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.714
5dt4 ATPAurora kinase A 2.7.11.1 0.713
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.712
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.712
1mq4 ADPAurora kinase A 2.7.11.1 0.711
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.710
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.709
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.709
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.708
4c3r ACPAurora kinase A 2.7.11.1 0.708
2pun ACPMethylthioribose kinase 2.7.1.100 0.707
4ysj ADPCalmodulin-like domain protein kinase / 0.706
4xlv ACPInsulin receptor 2.7.10.1 0.705
5dos ATPAurora kinase A 2.7.11.1 0.704
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.703
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.702
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.702
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.701
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.700
4dee ADPAurora kinase A 2.7.11.1 0.700
4gyi ADPUncharacterized protein / 0.700
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.700
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.699
5eg3 ACPFibroblast growth factor receptor 2 / 0.699
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.698
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.698
4q5h ANPProtein kinase OspG 2.7 0.698
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.697
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.696
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.696
3t8o ATPRhodopsin kinase / 0.694
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.693
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.692
3llt ANPProtein serine/threonine kinase-1 / 0.691
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.691
1ol6 ATPAurora kinase A 2.7.11.1 0.690
2pup ADPMethylthioribose kinase 2.7.1.100 0.690
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.690
2p0a ANPSynapsin-3 / 0.689
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.689
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.689
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
5dr2 ATPAurora kinase A 2.7.11.1 0.689
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.688
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.687
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.685
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.685
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.685
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.685
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.685
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.685
5dn3 ATPAurora kinase A 2.7.11.1 0.685
5drd ATPAurora kinase A 2.7.11.1 0.684
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.683
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.683
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.682
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.682
3qc9 ADPRhodopsin kinase / 0.681
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4o4e ATPKinase / 0.678
2pz5 ACPFibroblast growth factor receptor 2 / 0.677
2pzp ACPFibroblast growth factor receptor 2 / 0.677
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.677
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.676
4utd ACPAurora kinase A 2.7.11.1 0.676
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
5dt3 ATPAurora kinase A 2.7.11.1 0.674
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
1ol5 ADPAurora kinase A 2.7.11.1 0.673
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.673
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.672
3nie ANPMitogen-activated protein kinase / 0.672
3wo1 ADPAlanine--anticapsin ligase / 0.672
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.671
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.671
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.670
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.669
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.668
2pml ANPUncharacterized protein / 0.668
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.668
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.668
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.667
4n57 ADPAPH(2'')-Id / 0.667
5l8j ADPAurora kinase A 2.7.11.1 0.667
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.666
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.666
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
5l8l ADPAurora kinase A 2.7.11.1 0.666
3c4w ATPRhodopsin kinase / 0.665
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.665
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.665
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.665
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.665
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.664
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.662
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.662
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.662
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.662
4o4f ATPKinase / 0.662
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.660
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.660
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.660
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.660
3g8d ADPBiotin carboxylase 6.3.4.14 0.659
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4c3p ACPAurora kinase A 2.7.11.1 0.659
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.658
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.657
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.657
1i44 ACPInsulin receptor 2.7.10.1 0.656
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2pyw ADPMethylthioribose kinase 2.7.1.100 0.655
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.655
4qny ANPMitogen activated protein kinase, putative / 0.655
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
2hgs ADPGlutathione synthetase 6.3.2.3 0.654
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.654
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.654
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.654
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.653
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.653
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.653
2py3 ACPFibroblast growth factor receptor 2 / 0.652
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.652
2zdg ADPD-alanine--D-alanine ligase / 0.651
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.651
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.650
3g8c ADPBiotin carboxylase 6.3.4.14 0.650
5ce3 ADPProtein kinase YopO / 0.650