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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pax DHQ Poly [ADP-ribose] polymerase 1 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pax DHQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.834
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.734
1efy BZCPoly [ADP-ribose] polymerase 1 2.4.2.30 0.722
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.708
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.704
4avu LDRTankyrase-2 2.4.2.30 0.704
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.700
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.697
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.695
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.688
5ewk P34Putative secreted protein / 0.685
3ce0 P34Poly [ADP-ribose] polymerase 3 2.4.2.30 0.681
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.681
4bux F35Tankyrase-2 2.4.2.30 0.671
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.670
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.670
4pnr G18Tankyrase-2 2.4.2.30 0.669
4bus 32FTankyrase-2 2.4.2.30 0.667
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.667
4bjc RPBTankyrase-2 2.4.2.30 0.663
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
3u9y 09LTankyrase-2 2.4.2.30 0.656
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.655
3b78 NADExotoxin A 2.4.2.36 0.655
4buu F38Tankyrase-2 2.4.2.30 0.654
4e5f 0N7Polymerase acidic protein / 0.654
5aku 29FTankyrase-2 2.4.2.30 0.654
4but 31FTankyrase-2 2.4.2.30 0.651