sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 1.039 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.952 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.914 | |
| 1u3v | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.910 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.910 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.908 | |
| 1axe | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.902 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.885 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.880 | |
| 4dlb | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.873 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.867 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.866 | |
| 1ht0 | NAD | Alcohol dehydrogenase 1C | 1.1.1.1 | 0.864 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.861 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.852 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.851 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.850 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.848 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.848 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5kcp | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5kj6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.847 | |
| 5kje | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.844 | |
| 4dwv | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.842 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.842 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.838 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.838 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.838 | |
| 5kj1 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.835 | |
| 2jhf | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.833 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.833 | |
| 4ng5 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.828 | |
| 1a71 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.825 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.814 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.813 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.813 | |
| 1hld | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.811 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.807 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.805 | |
| 1adb | CND | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.798 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.794 | |
| 1hdz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.787 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.787 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.778 | |
| 1hsz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.778 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.778 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.775 | |
| 4w6z | 8ID | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.774 | |
| 1axg | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.772 | |
| 4c4o | NAD | SADH | / | 0.767 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.763 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.762 | |
| 1r37 | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.761 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.760 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.759 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.757 | |
| 1agn | NAD | Alcohol dehydrogenase class 4 mu/sigma chain | 1.1.1.1 | 0.754 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.754 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.747 | |
| 1kol | NAD | Glutathione-independent formaldehyde dehydrogenase | / | 0.745 | |
| 4cpd | NAD | Alcohol dehydrogenase | / | 0.745 | |
| 2dfd | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.742 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.742 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.742 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.739 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.737 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.736 | |
| 2eer | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.735 | |
| 5mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.733 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.729 | |
| 6adh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.724 | |
| 1lld | NAD | L-lactate dehydrogenase 2 | 1.1.1.27 | 0.723 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.722 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.719 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.717 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.717 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.716 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.715 | |
| 4j49 | NAD | Uncharacterized protein | / | 0.715 | |
| 1pl6 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.713 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.712 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.711 | |
| 4jk3 | NAD | Uncharacterized protein | / | 0.710 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.709 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.707 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.705 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.705 | |
| 3two | NDP | Mannitol dehydrogenase | / | 0.704 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.702 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.702 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.701 | |
| 4j43 | NAD | Uncharacterized protein | / | 0.698 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.697 | |
| 4j4b | NAI | Uncharacterized protein | / | 0.697 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.696 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.696 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.695 | |
| 2cdc | NAP | Glucose 1-dehydrogenase | / | 0.695 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.692 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.688 | |
| 1j5p | NAD | L-aspartate dehydrogenase | 1.4.1.21 | 0.688 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.688 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.686 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.685 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.684 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.683 | |
| 4weq | NAP | NAD-dependent dehydrogenase | / | 0.682 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.680 | |
| 3kbo | NDP | Glyoxylate/hydroxypyruvate reductase A | / | 0.680 | |
| 1m75 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.679 | |
| 4j49 | NAI | Uncharacterized protein | / | 0.679 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.679 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.679 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.678 | |
| 2vwh | NAP | Glucose 1-dehydrogenase | / | 0.678 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.678 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.677 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.677 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.677 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.676 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.676 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.674 | |
| 1m76 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.672 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.672 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.670 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.669 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.668 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.668 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.667 | |
| 3abi | NAD | Uncharacterized protein | / | 0.667 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.666 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.664 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.664 | |
| 3d64 | NAD | Adenosylhomocysteinase | / | 0.663 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.662 | |
| 2b5v | NAP | Glucose 1-dehydrogenase | / | 0.662 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.662 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.660 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.659 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.659 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.656 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.656 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.654 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.654 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.654 | |
| 4ros | APR | Malate dehydrogenase | / | 0.654 | |
| 2vhw | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.653 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.652 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.650 |