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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jnk ANP Mitogen-activated protein kinase 10 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 1.055
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.814
1cm8 ANPMitogen-activated protein kinase 12 / 0.760
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.751
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.750
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.749
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.741
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.739
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.737
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.736
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.734
2pul ACPMethylthioribose kinase 2.7.1.100 0.731
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.729
2dwb ANPAurora kinase A 2.7.11.1 0.729
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.729
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.728
5dr2 ATPAurora kinase A 2.7.11.1 0.727
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.725
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.724
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.718
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
3t8o ATPRhodopsin kinase / 0.715
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.713
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.713
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.713
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.713
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.712
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.712
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.708
3qc9 ADPRhodopsin kinase / 0.707
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.705
4bn1 ADPAurora kinase A 2.7.11.1 0.705
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.704
2pml ANPUncharacterized protein / 0.703
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.702
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.702
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.701
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4xlv ACPInsulin receptor 2.7.10.1 0.701
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.700
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.699
4dee ADPAurora kinase A 2.7.11.1 0.699
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.698
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
2pyw ADPMethylthioribose kinase 2.7.1.100 0.697
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.697
4ceg ADPAurora kinase A 2.7.11.1 0.697
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.697
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
4o4d ATPKinase / 0.697
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.693
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.693
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.692
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.692
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.691
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.691
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.690
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.688
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.685
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
2pzp ACPFibroblast growth factor receptor 2 / 0.684
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.683
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.683
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.683
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.680
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.679
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4gyi ADPUncharacterized protein / 0.679
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.677
4o1p ANPRibonuclease L / 0.677
1m0w ANPGlutathione synthetase 6.3.2.3 0.676
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.676
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.674
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.674
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.671
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
3g8c ADPBiotin carboxylase 6.3.4.14 0.670
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.670
1mq4 ADPAurora kinase A 2.7.11.1 0.669
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.669
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
5eg3 ACPFibroblast growth factor receptor 2 / 0.669
2py3 ACPFibroblast growth factor receptor 2 / 0.668
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
5dn3 ATPAurora kinase A 2.7.11.1 0.668
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
2wtk ANPSTE20-related kinase adapter protein alpha / 0.666
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.665
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.665
3ori AGSSerine/threonine protein kinase / 0.665
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.665
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.664
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.664
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.663
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.663
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.663
5ce3 ADPProtein kinase YopO / 0.663
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.662
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.662
4qny ANPMitogen activated protein kinase, putative / 0.662
4utd ACPAurora kinase A 2.7.11.1 0.662
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.661
5dos ATPAurora kinase A 2.7.11.1 0.661
1u54 ACPActivated CDC42 kinase 1 / 0.660
4c3p ACPAurora kinase A 2.7.11.1 0.660
5byl GCPBifunctional AAC/APH 2.3.1 0.659
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.658
4o4f ATPKinase / 0.658
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.657
4o4e ATPKinase / 0.657
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.656
3bu5 ATPInsulin receptor 2.7.10.1 0.656
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.654
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.654
2vqd AP2Biotin carboxylase 6.3.4.14 0.654
3c4w ATPRhodopsin kinase / 0.654
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.654
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.653
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.652
1pk8 ATPSynapsin-1 / 0.652
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.652
4c3r ACPAurora kinase A 2.7.11.1 0.652
4ysj ADPCalmodulin-like domain protein kinase / 0.652
5dt3 ATPAurora kinase A 2.7.11.1 0.652
2pun ACPMethylthioribose kinase 2.7.1.100 0.651
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.651
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.651
5iqh GNPBifunctional AAC/APH 2.3.1 0.651
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.650
5bn3 ADPV-type ATP synthase alpha chain / 0.650
5bn3 ADPNEQ263 / 0.650