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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ir3 ANP Insulin receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ir3 ANPInsulin receptor 2.7.10.1 1.030
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.728
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.711
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.708
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.706
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.699
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.696
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.688
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.688
2pwl ACPFibroblast growth factor receptor 2 / 0.687
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.683
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.683
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.682
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
1cm8 ANPMitogen-activated protein kinase 12 / 0.678
1qru ATPGlutamine--tRNA ligase 6.1.1.18 0.678
2pyw ADPMethylthioribose kinase 2.7.1.100 0.677
3t8o ATPRhodopsin kinase / 0.677
4mv8 ACPBiotin carboxylase 6.3.4.14 0.676
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.675
3wnz ADPAlanine--anticapsin ligase / 0.674
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.674
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.674
4xlv ACPInsulin receptor 2.7.10.1 0.674
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.671
1qrs ATPGlutamine--tRNA ligase 6.1.1.18 0.669
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.668
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.667
5l6w AGSLIM domain kinase 1 2.7.11.1 0.667
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.666
2olc ADPMethylthioribose kinase 2.7.1.100 0.665
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.664
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.664
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.663
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.662
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.662
2pui ADPMethylthioribose kinase 2.7.1.100 0.662
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.662
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.662
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.662
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.661
3bu5 ATPInsulin receptor 2.7.10.1 0.660
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.660
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.659
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.659
2c2a ADPSensor histidine kinase / 0.659
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.659
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.659
2pbz ATPUncharacterized protein / 0.658
2wqe ADPAurora kinase A 2.7.11.1 0.658
4ceg ADPAurora kinase A 2.7.11.1 0.658
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
2pml ANPUncharacterized protein / 0.656
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.656
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4mv3 ACPBiotin carboxylase 6.3.4.14 0.656
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.656
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.655
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.655
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.655
4qny ANPMitogen activated protein kinase, putative / 0.654
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.653
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
5l8l ADPAurora kinase A 2.7.11.1 0.653
2py3 ACPFibroblast growth factor receptor 2 / 0.652
4ffm ADPUncharacterized protein / 0.652
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.651
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.651
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.651
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.651
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1hpu A12Protein UshA 3.1.3.5 0.650
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.650
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.650