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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1h2h NAD L-aspartate dehydrogenase 1.4.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1h2h NADL-aspartate dehydrogenase 1.4.1.21 1.111
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.893
1uxj NADMalate dehydrogenase / 0.714
2dc1 NADProbable L-aspartate dehydrogenase / 0.702
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.700
2aa3 AP0L-lactate dehydrogenase / 0.698
1pzh NADLactate dehydrogenase / 0.696
2dfv NADL-threonine 3-dehydrogenase / 0.696
2d8a NADL-threonine 3-dehydrogenase / 0.695
1sow NADL-lactate dehydrogenase 1.1.1.27 0.694
1uxk NADMalate dehydrogenase / 0.691
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.691
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.689
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.688
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.680
2hu2 NADC-terminal binding protein 1 / 0.680
4b67 FADL-ornithine N(5)-monooxygenase / 0.680
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.679
3h5n ATPMccB protein / 0.679
3wv7 ADPHmd co-occurring protein HcgE / 0.679
1pzf A3DLactate dehydrogenase / 0.678
1p1i NADInositol-3-phosphate synthase 5.5.1.4 0.675
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.674
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.673
2a92 NAIL-lactate dehydrogenase / 0.673
1bdm NAXMalate dehydrogenase / 0.670
1hku NADC-terminal-binding protein 1 1.1.1 0.670
4nzh FADL-ornithine N(5)-monooxygenase / 0.670
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.669
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.668
1bw9 NADPhenylalanine dehydrogenase / 0.667
1pzg A3DLactate dehydrogenase / 0.667
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.667
2ejv NADL-threonine 3-dehydrogenase / 0.667
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.666
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.665
4aos FADSteroid monooxygenase / 0.665
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.664
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.663
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.663
4weq NAPNAD-dependent dehydrogenase / 0.663
1b8v NADMalate dehydrogenase / 0.662
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.662
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.661
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.661
2gvc FADThiol-specific monooxygenase 1.14.13 0.661
2vhx NADAlanine dehydrogenase 1.4.1.1 0.661
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.660
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.660
4dsg FADUncharacterized protein / 0.660
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.659
2fkn NADUrocanate hydratase 4.2.1.49 0.659
4z0p NDPNAD-dependent dehydrogenase / 0.659
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.658
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.658
4b69 FADL-ornithine N(5)-monooxygenase / 0.658
4lcj NADC-terminal-binding protein 2 / 0.658
4tm1 FDAKtzI / 0.658
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.657
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.656
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.655
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.655
4b63 FADL-ornithine N(5)-monooxygenase / 0.655
4cuk NAID-lactate dehydrogenase / 0.655
4tlz FADKtzI / 0.655
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.654
3kb6 NADD-lactate dehydrogenase / 0.654
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.654
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
3c96 FADFlavin-containing monooxygenase / 0.653
3gvh NADMalate dehydrogenase / 0.653
5cku FADL-ornithine N(5)-monooxygenase / 0.653
1d7l RFLp-hydroxybenzoate hydroxylase / 0.652
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.652
3jv7 NADSecondary alcohol dehydrogenase / 0.652
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.652
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.652
5a1t NAIL-lactate dehydrogenase / 0.652
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.651
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.651
3d64 NADAdenosylhomocysteinase / 0.651
3lsh FADPyranose 2-oxidase / 0.651
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
3utf FDAUDP-galactopyranose mutase / 0.651
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650
2gsd NADFormate dehydrogenase / 0.650
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.650
3mj4 FADUDP-galactopyranose mutase / 0.650
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.650
4j49 NADUncharacterized protein / 0.650