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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yu153NAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4yu153NAldose reductase1.1.1.211.000
3m4h388Aldose reductase1.1.1.210.723
3lboLDTAldose reductase1.1.1.210.722
3lqlLDTAldose reductase1.1.1.210.703
1t40ID5Aldose reductase1.1.1.210.694
2duxZSTAldose reductase1.1.1.210.675
1z3n3NAAldose reductase1.1.1.210.671
3lz5LDTAldose reductase1.1.1.210.664
1z8962PAldose reductase1.1.1.210.658
2i17LDTAldose reductase1.1.1.210.654
2pdg47DAldose reductase1.1.1.210.654
2hvoZSTAldose reductase1.1.1.210.652
3mb9ZSTAldose reductase1.1.1.210.648
2qxwLDTAldose reductase1.1.1.210.646
2ikj393Aldose reductase1.1.1.210.644
3mc5393Aldose reductase1.1.1.210.642
3ld5LDTAldose reductase1.1.1.210.639
2pdxZSTAldose reductase1.1.1.210.634
1t41ID5Aldose reductase1.1.1.210.633
3m64393Aldose reductase1.1.1.210.625
4gca2X9Aldose reductase1.1.1.210.622
3lenZSTAldose reductase1.1.1.210.617
1us0LDTAldose reductase1.1.1.210.616
2pdkSBIAldose reductase1.1.1.210.616
2pdc393Aldose reductase1.1.1.210.613
2pzn393Aldose reductase1.1.1.210.607
3ghtLDTAldose reductase1.1.1.210.607
3ghuLDTAldose reductase1.1.1.210.606
2fz9ZSTAldose reductase1.1.1.210.605
2pdp393Aldose reductase1.1.1.210.601
2pdu393Aldose reductase1.1.1.210.601
2i16LDTAldose reductase1.1.1.210.600
2iki388Aldose reductase1.1.1.210.596
2duzZSTAldose reductase1.1.1.210.593
2pdbZSTAldose reductase1.1.1.210.592
1pwlBFIAldose reductase1.1.1.210.591
2hv5ZSTAldose reductase1.1.1.210.590
3t423T4Aldose reductase1.1.1.210.588
3m0iZSTAldose reductase1.1.1.210.587
2pdj393Aldose reductase1.1.1.210.582
2pf8NDPAldose reductase1.1.1.210.582
2fzdTOLAldose reductase1.1.1.210.579
2ikhLITAldose reductase1.1.1.210.579
3g5eQ74Aldose reductase1.1.1.210.579
2pd5ZSTAldose reductase1.1.1.210.577
2pdn47DAldose reductase1.1.1.210.577
1frbZSTAldose reductase-related protein 2/0.576
3ghsLDTAldose reductase1.1.1.210.573
2pdfZSTAldose reductase1.1.1.210.570
2dv0ZSTAldose reductase1.1.1.210.569
2pdh47DAldose reductase1.1.1.210.561
3ghrLDTAldose reductase1.1.1.210.552
1el3I84Aldose reductase1.1.1.210.549
2fz8ZSTAldose reductase1.1.1.210.547
1ah3TOLAldose reductase1.1.1.210.538
2agtFIDAldose reductase1.1.1.210.537
1ieiZESAldose reductase1.1.1.210.532
2pd9FIDAldose reductase1.1.1.210.522
2f2kTGGAldose reductase1.1.1.210.518
2pdq47DAldose reductase1.1.1.210.517
2fzbTOLAldose reductase1.1.1.210.495
1zuaTOLAldo-keto reductase family 1 member B101.1.10.491
3v35NTIAldose reductase1.1.1.210.490
1ekoI84Aldose reductase1.1.1.210.489
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.481
1yw7A41Methionine aminopeptidase 2/0.475
3mjrAC2Deoxycytidine kinase2.7.1.740.471
2ipjFFAAldo-keto reductase family 1 member C2/0.468
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
2is72CLAldose reductase1.1.1.210.465
2wmdZZ0NmrA-like family domain-containing protein 1/0.465
4ga8SBIAldo-keto reductase family 1 member B101.1.10.464
2oazI96Methionine aminopeptidase 2/0.462
5liu388Aldo-keto reductase family 1 member B101.1.10.461
4wevSUZAldo-keto reductase family 1 member B101.1.10.460
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.459
2xupTZ5Acetylcholinesterase3.1.1.70.459
4dbw511Aldo-keto reductase family 1 member C3/0.459
2xufTZ4Acetylcholinesterase3.1.1.70.458
2ga2A19Methionine aminopeptidase 2/0.457
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.457
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.457
2iqdLPAAldose reductase1.1.1.210.456
2xuqTZ4Acetylcholinesterase3.1.1.70.455
3u2cSUZAldose reductase1.1.1.210.455
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
1lkeDOGBilin-binding protein/0.453
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
4pnmNU1Tankyrase-22.4.2.300.453
2pdlTOLAldose reductase1.1.1.210.452
2pdwFIDAldose reductase1.1.1.210.452
4i5xFLFAldo-keto reductase family 1 member B101.1.10.452
3aosJH2Hemolymph juvenile hormone binding protein/0.451
2xujTZ5Acetylcholinesterase3.1.1.70.448
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.448
4xo7ASDAldo-keto reductase family 1 member C2/0.448
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
1vkgCRIHistone deacetylase 83.5.1.980.447
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.447
3p2vDOYAldose reductase1.1.1.210.447
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1yw9A84Methionine aminopeptidase 2/0.444
2gywOBIAcetylcholinesterase3.1.1.70.444
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.444
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2f3815MAldo-keto reductase family 1 member C3/0.443
2zs9ADPPantothenate kinase2.7.1.330.443
4stdBFSScytalone dehydratase4.2.1.940.443
1dgbNDPCatalase1.11.1.60.442
1h22E10Acetylcholinesterase3.1.1.70.442
2cbqTH2Neocarzinostatin/0.442
4jtqNAPAldo-keto reductase family 1 member C2/0.442
3c3xNAPEugenol synthase 11.1.1.3180.441
4k4eK4ETankyrase-12.4.2.300.441
1gt5BZQOdorant-binding protein/0.440
1i75NOJCyclomaltodextrin glucanotransferase2.4.1.190.440
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.440
4e0u0MVCyclic dipeptide N-prenyltransferase/0.440
4jq3ZOMAldo-keto reductase family 1 member C2/0.440