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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.11.000
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.592
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.571
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.497
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.496
3zep1NXTyrosine-protein kinase JAK32.7.10.20.494
4qmpDKISerine/threonine-protein kinase 242.7.11.10.494
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.489
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.488
2wxvWXVCyclin-dependent kinase 22.7.11.220.487
4erwSTUCyclin-dependent kinase 22.7.11.220.487
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.487
4jqeANPCasein kinase II subunit alpha2.7.11.10.484
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.483
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.482
3r9dX6BCyclin-dependent kinase 22.7.11.220.480
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.480
3uli1N3Cyclin-dependent kinase 22.7.11.220.478
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.477
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.477
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.476
3s1h56ZCyclin-dependent kinase 22.7.11.220.476
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.476
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.476
4qmySTUSerine/threonine-protein kinase 242.7.11.10.475
1pkdUCNCyclin-dependent kinase 22.7.11.220.474
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
2i40BLZCyclin-dependent kinase 22.7.11.220.473
1g5sI17Cyclin-dependent kinase 22.7.11.220.472
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.472
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.470
3rak03ZCyclin-dependent kinase 22.7.11.220.470
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.469
4qmzB49Serine/threonine-protein kinase 242.7.11.10.468
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.467
2b7aIZATyrosine-protein kinase JAK2/0.466
2hog710Serine/threonine-protein kinase Chk12.7.11.10.466
4gmy0X5Tyrosine-protein kinase JAK2/0.464
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.463
4fx360KCyclin-dependent kinase 22.7.11.220.463
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.462
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.462
3rmf20ZCyclin-dependent kinase 22.7.11.220.461
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.460
2uzlC94Cyclin-dependent kinase 22.7.11.220.460
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.460
3ral04ZCyclin-dependent kinase 22.7.11.220.460
1tj0FADBifunctional protein PutA1.5.5.20.459
2x1nX1NCyclin-dependent kinase 22.7.11.220.459
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.459
2wipP49Cyclin-dependent kinase 22.7.11.220.457
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.457
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.455
1zrzBI1Protein kinase C iota type2.7.11.130.455
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.454
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.454
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.454
5e8wSTUTGF-beta receptor type-12.7.11.300.454
1gih1PUCyclin-dependent kinase 22.7.11.220.453
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.453
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.452
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.452
3a7hATPSerine/threonine-protein kinase 242.7.11.10.452
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1oguST8Cyclin-dependent kinase 22.7.11.220.451
2iw84SPCyclin-dependent kinase 22.7.11.220.451
2j0m4STFocal adhesion kinase 12.7.10.20.451
3biz61EWee1-like protein kinase2.7.10.20.451
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.451
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.451
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
4acm7YGCyclin-dependent kinase 22.7.11.220.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
3rpv26ZCyclin-dependent kinase 22.7.11.220.449
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.449
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
4qnaX11Serine/threonine-protein kinase 242.7.11.10.449
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.448
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.448
1h1r6CPCyclin-dependent kinase 22.7.11.220.447
1oiyN41Cyclin-dependent kinase 22.7.11.220.447
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.447
1fvv107Cyclin-dependent kinase 22.7.11.220.446
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4bcnT9NCyclin-dependent kinase 22.7.11.220.446
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.446
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1h1s4SPCyclin-dependent kinase 22.7.11.220.445
3iok1P6Tyrosine-protein kinase JAK2/0.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.445
1jpaANPEphrin type-B receptor 22.7.10.10.444
2eufLQQCyclin-dependent kinase 62.7.11.220.444
2uzdC85Cyclin-dependent kinase 22.7.11.220.444
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
4c61LMMTyrosine-protein kinase JAK2/0.444
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.444
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.444
1oi9N20Cyclin-dependent kinase 22.7.11.220.443
3r9oZ71Cyclin-dependent kinase 22.7.11.220.443
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.443
1gij2PUCyclin-dependent kinase 22.7.11.220.442
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.442
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.442
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
2xikJ60Serine/threonine-protein kinase 252.7.11.10.442
4e4m0NHTyrosine-protein kinase JAK2/0.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
1ke9LS5Cyclin-dependent kinase 22.7.11.220.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.441
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.441
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.441
3rk708ZCyclin-dependent kinase 22.7.11.220.441
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4q71FADBifunctional protein PutA/0.441
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.440
2c5nCK8Cyclin-dependent kinase 22.7.11.220.440
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
4c62XWWTyrosine-protein kinase JAK2/0.440
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.440
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.440
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
5cvhADPCasein kinase II subunit alpha2.7.11.10.440