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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.53

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.531.000
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.589
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.582
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.568
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.568
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.564
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.562
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.559
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.553
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.547
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.538
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.536
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.536
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.535
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.532
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.531
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.531
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.530
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.529
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.524
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.516
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.513
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.510
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.506
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.504
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.500
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.498
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.492
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.488
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.486
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.482
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.477
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.477
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.477
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.475
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.475
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.472
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.459
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3v94WYQPhosphodiesterase/0.455
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442