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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4knmE1ECarbonic anhydrase 134.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4knmE1ECarbonic anhydrase 134.2.1.11.000
3b4fTUOCarbonic anhydrase 24.2.1.10.587
3k2fNKXCarbonic anhydrase 24.2.1.10.584
1i90INMCarbonic anhydrase 24.2.1.10.579
1bnnAL1Carbonic anhydrase 24.2.1.10.578
3ffpLC1Carbonic anhydrase 24.2.1.10.576
4pxxCHDCarbonic anhydrase 24.2.1.10.576
3dazMZMCarbonic anhydrase 24.2.1.10.570
1if6FBUCarbonic anhydrase 24.2.1.10.569
1a42BZUCarbonic anhydrase 24.2.1.10.568
1i91INQCarbonic anhydrase 24.2.1.10.567
4hu1V13Carbonic anhydrase 134.2.1.10.562
1ttm667Carbonic anhydrase 24.2.1.10.560
2eu3FF3Carbonic anhydrase 24.2.1.10.560
1bnwTPDCarbonic anhydrase 24.2.1.10.558
2h15B19Carbonic anhydrase 24.2.1.10.557
1bn1AL5Carbonic anhydrase 24.2.1.10.556
1if4FBSCarbonic anhydrase 24.2.1.10.555
3m67E36Carbonic anhydrase 24.2.1.10.552
4n16CHDCarbonic anhydrase 24.2.1.10.551
1g52F2BCarbonic anhydrase 24.2.1.10.549
3hkuTORCarbonic anhydrase 24.2.1.10.549
1xpz4TZCarbonic anhydrase 24.2.1.10.542
4knnE1FCarbonic anhydrase 134.2.1.10.542
1bn4AL9Carbonic anhydrase 24.2.1.10.541
1bntAL2Carbonic anhydrase 24.2.1.10.539
1bnvAL7Carbonic anhydrase 24.2.1.10.539
2wehFB1Carbonic anhydrase 24.2.1.10.539
1xq04TRCarbonic anhydrase 24.2.1.10.537
3dd82C7Carbonic anhydrase 24.2.1.10.537
3s9tE49Carbonic anhydrase 24.2.1.10.537
1bn3AL6Carbonic anhydrase 24.2.1.10.535
3d9zD9ZCarbonic anhydrase 24.2.1.10.535
3eft3BSCarbonic anhydrase 24.2.1.10.534
3s8xE59Carbonic anhydrase 24.2.1.10.534
3sbhE65Carbonic anhydrase 24.2.1.10.533
3betCTFCarbonic anhydrase 24.2.1.10.530
3m2nJ74Carbonic anhydrase 24.2.1.10.530
3nb5R21Carbonic anhydrase 24.2.1.10.530
3mzcS6ICarbonic anhydrase 24.2.1.10.528
3po6DT9Carbonic anhydrase 24.2.1.10.528
3sbiE90Carbonic anhydrase 24.2.1.10.528
3bl1BL1Carbonic anhydrase 24.2.1.10.527
1i9nIOACarbonic anhydrase 24.2.1.10.526
1zsbAZMCarbonic anhydrase 24.2.1.10.526
1bnmAL8Carbonic anhydrase 24.2.1.10.525
3zncBZ1Carbonic anhydrase 44.2.1.10.525
3oysOYSCarbonic anhydrase 24.2.1.10.523
1i8zINLCarbonic anhydrase 24.2.1.10.522
3dc3AZMCarbonic anhydrase 24.2.1.10.522
1bnqAL4Carbonic anhydrase 24.2.1.10.521
4itp1GDCarbonic anhydrase 24.2.1.10.521
1g1dFSBCarbonic anhydrase 24.2.1.10.520
4itoMPXCarbonic anhydrase 24.2.1.10.519
3t82SG4Carbonic anhydrase 24.2.1.10.518
4kniE1ECarbonic anhydrase 24.2.1.10.518
2wd2MS5Carbonic anhydrase 24.2.1.10.516
2weoFBWCarbonic anhydrase 24.2.1.10.516
4ilx1EZCarbonic anhydrase 24.2.1.10.516
3dcsMZMCarbonic anhydrase 24.2.1.10.515
3m2yBE0Carbonic anhydrase 24.2.1.10.515
3m96E38Carbonic anhydrase 24.2.1.10.515
1oklMNSCarbonic anhydrase 24.2.1.10.514
1oq5CELCarbonic anhydrase 24.2.1.10.514
1if5FBTCarbonic anhydrase 24.2.1.10.513
3qykIE2Carbonic anhydrase 24.2.1.10.513
2x7tWZBCarbonic anhydrase 24.2.1.10.511
3m5eJDRCarbonic anhydrase 24.2.1.10.511
1cilETSCarbonic anhydrase 24.2.1.10.510
3m98E02Carbonic anhydrase 24.2.1.10.510
3mhlJ71Carbonic anhydrase 24.2.1.10.510
1g4oBSBCarbonic anhydrase 24.2.1.10.508
3saxE50Carbonic anhydrase 24.2.1.10.507
3ml2SU0Carbonic anhydrase 24.2.1.10.506
4kp5E1FCarbonic anhydrase 124.2.1.10.506
3kigDA4Carbonic anhydrase 24.2.1.10.505
4lu3AZMCarbonic anhydrase 144.2.1.10.505
1kwrSG2Carbonic anhydrase 24.2.1.10.502
3igpDT7Carbonic anhydrase 24.2.1.10.502
3n2pAYXCarbonic anhydrase 24.2.1.10.502
4kp8E1GCarbonic anhydrase 124.2.1.10.502
1g4jFFBCarbonic anhydrase 24.2.1.10.500
1g54FFBCarbonic anhydrase 24.2.1.10.499
2x7uWZACarbonic anhydrase 24.2.1.10.499
3mdzEZLCarbonic anhydrase 74.2.1.10.499
4kap1QVCarbonic anhydrase 24.2.1.10.499
1i9mINWCarbonic anhydrase 24.2.1.10.498
1kwqSG1Carbonic anhydrase 24.2.1.10.498
3f4xKLTCarbonic anhydrase 24.2.1.10.498
4m2rBZ1Carbonic anhydrase 24.2.1.10.498
4bf6X0QCarbonic anhydrase 24.2.1.10.497
5fltVJJCarbonic anhydrase 24.2.1.10.497
3m40J45Carbonic anhydrase 24.2.1.10.496
3mhoJ43Carbonic anhydrase 24.2.1.10.495
4knjE1FCarbonic anhydrase 24.2.1.10.495
3lxeTORCarbonic anhydrase 14.2.1.10.493
1g45FSBCarbonic anhydrase 24.2.1.10.492
3t85SG7Carbonic anhydrase 24.2.1.10.490
1jd0AZMCarbonic anhydrase 124.2.1.10.488
3mnaDWHCarbonic anhydrase 24.2.1.10.488
3t84SG6Carbonic anhydrase 24.2.1.10.487
4iwz1GOCarbonic anhydrase 24.2.1.10.484
3oimVZ5Carbonic anhydrase 24.2.1.10.481
1if8SBSCarbonic anhydrase 24.2.1.10.479
3n0nP9BCarbonic anhydrase 24.2.1.10.479
3n4bWWZCarbonic anhydrase 24.2.1.10.478
4m2vBZ1Carbonic anhydrase 24.2.1.10.477
1i9pIOECarbonic anhydrase 24.2.1.10.476
3mmfD9HCarbonic anhydrase 24.2.1.10.476
1cnwEG1Carbonic anhydrase 24.2.1.10.474
1i9qIOFCarbonic anhydrase 24.2.1.10.474
2wejFB2Carbonic anhydrase 24.2.1.10.474
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.474
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.474
3ni5C1HCarbonic anhydrase 24.2.1.10.472
3oikWZBCarbonic anhydrase 24.2.1.10.472
1if7SBRCarbonic anhydrase 24.2.1.10.471
4ht2V50Carbonic anhydrase 124.2.1.10.467
2bxqIMNSerum albumin/0.465
1bnuAL3Carbonic anhydrase 24.2.1.10.464
1zdwFLVPrenyltransferase/0.462
2powI7CCarbonic anhydrase 24.2.1.10.460
1okmSABCarbonic anhydrase 24.2.1.10.459
3v2jAZMCarbonic anhydrase 24.2.1.10.458
3oy0OY0Carbonic anhydrase 24.2.1.10.457
1oknSTBCarbonic anhydrase 24.2.1.10.456
3d8wD8WCarbonic anhydrase 24.2.1.10.456
3fw3ETSCarbonic anhydrase 44.2.1.10.456
1kqwRTLCellular retinol-binding protein type II/0.455
2wegFBVCarbonic anhydrase 24.2.1.10.455
3f7bAG5Carbonic anhydrase 44.2.1.10.455
3f7uAG4Carbonic anhydrase 44.2.1.10.455
4gukP2GNeuronal calcium sensor 1/0.454
3n3jWWVCarbonic anhydrase 24.2.1.10.453
4a83DXCMajor pollen allergen Bet v 1-A/0.453
4k13ETSCarbonic anhydrase 24.2.1.10.453
4a862ANMajor pollen allergen Bet v 1-A/0.452
3fr5I4AFatty acid-binding protein, adipocyte/0.451
4qzuRTLRetinol-binding protein 2/0.451
3mhiJ90Carbonic anhydrase 24.2.1.10.449
3myqE27Carbonic anhydrase 24.2.1.10.449
4mo82VQCarbonic anhydrase 24.2.1.10.449
1towCRZFatty acid-binding protein, adipocyte/0.448
4uovAZMCarbonate dehydratase/0.448
1h50FMNPentaerythritol tetranitrate reductase/0.447
2ejvNADL-threonine 3-dehydrogenase/0.447
2ea4F79Methionine aminopeptidase 2/0.446
3oyqOYQCarbonic anhydrase 24.2.1.10.446
4h6pFMNChromate reductase/0.446
1cqp803Integrin alpha-L/0.443
1t7o152Carnitine O-acetyltransferase2.3.1.70.443
1tkaN3TTransketolase 12.2.1.10.443
2rqfJH3Hemolymph juvenile hormone binding protein/0.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4iah1DXAlr2278 protein/0.442
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.442
1eouSMSCarbonic anhydrase 24.2.1.10.441
2q1qOSPCarbonic anhydrase 24.2.1.10.441
3junAKDPhenazine biosynthesis protein A/B/0.441
3p62FMNPentaerythritol tetranitrate reductase/0.441
4a86H35Major pollen allergen Bet v 1-A/0.441
1yw9A84Methionine aminopeptidase 2/0.440
3dd0EZLCarbonic anhydrase 24.2.1.10.440
4q0kGA3Phytohormone-binding protein/0.440