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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4igfCHVEnoyl-acyl carrier reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4igfCHVEnoyl-acyl carrier reductase/1.000
1d7oTCLEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.535
4x5fFOLDihydrofolate reductase1.5.1.30.472
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
2e0nSAHPrecorrin-2 C20-methyltransferase/0.460
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.460
2ga2A19Methionine aminopeptidase 2/0.459
4hcy0YNTransketolase/0.457
1dr3HBIDihydrofolate reductase1.5.1.30.456
4g090VDHistidinol dehydrogenase/0.455
1f20FADNitric oxide synthase, brain1.14.13.390.453
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.452
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.452
1rneC60Renin3.4.23.150.451
2xufTZ4Acetylcholinesterase3.1.1.70.451
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3elePLPAminotransferase/0.449
4bfxZVXPantothenate kinase2.7.1.330.449
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.448
3h3qH13Collagen type IV alpha-3-binding protein/0.448
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.448
4g95OAGDihydrofolate reductase1.5.1.30.448
1blzACVIsopenicillin N synthase1.21.3.10.447
1mvsDTMDihydrofolate reductase1.5.1.30.447
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4mv1ADPBiotin carboxylase6.3.4.140.446
4o1mNADEnoyl-acyl carrier reductase/0.446
5cc9DDFDihydrofolate reductase1.5.1.30.446
1uzwCDHIsopenicillin N synthase1.21.3.10.445
1xe65FPPlasmepsin-23.4.23.390.444
1dr5NAPDihydrofolate reductase1.5.1.30.443
1p0pBCHCholinesterase3.1.1.80.443
2ea2F77Methionine aminopeptidase 2/0.443
4b7zQ4QAcetylcholinesterase3.1.1.70.443
5fd8A5APutative carboxypeptidase yocD/0.443
2jn3JN3Fatty acid-binding protein, liver/0.442
3oafOAGDihydrofolate reductase1.5.1.30.442
4kbyC2EStimulator of interferon genes protein/0.442
2ea4F79Methionine aminopeptidase 2/0.441
2g1o2IGRenin3.4.23.150.441
3s3vTOPDihydrofolate reductase1.5.1.30.441
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4tjy3GNTankyrase-22.4.2.300.441
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.440
1qiqACCIsopenicillin N synthase1.21.3.10.440
2xuoTZ4Acetylcholinesterase3.1.1.70.440
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.440
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.440