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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hbw14ZBromodomain-containing protein 4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hbw14ZBromodomain-containing protein 4/1.000
4c67L5SBromodomain-containing protein 4/0.636
4hxr1A4Bromodomain-containing protein 4/0.626
4gpj0Q1Bromodomain-containing protein 4/0.574
4alhA9PBromodomain-containing protein 2/0.566
4aknS5BBromodomain-containing protein 2/0.560
4lr61XABromodomain-containing protein 4/0.554
4uyf73BBromodomain-containing protein 2/0.548
4cfkLY2Bromodomain-containing protein 4/0.546
4hxs1A3Bromodomain-containing protein 4/0.542
4hby13FBromodomain-containing protein 4/0.538
4men25KBromodomain-containing protein 4/0.534
4j0s1H3Bromodomain-containing protein 4/0.532
5bt52LOBromodomain-containing protein 2/0.525
4mep24YBromodomain-containing protein 4/0.521
4ogiR78Bromodomain-containing protein 4/0.521
4alg1GHBromodomain-containing protein 2/0.519
4nr82LLBromodomain-containing protein 4/0.518
4j1p1K0Bromodomain-containing protein 2/0.516
3aqaBYHBromodomain-containing protein 2/0.513
4bw39BMBromodomain-containing protein 4/0.513
4flpJQ1Bromodomain testis-specific protein/0.512
4hxm1A8Bromodomain-containing protein 4/0.511
4hxn1A7Bromodomain-containing protein 4/0.510
4c66H4CBromodomain-containing protein 4/0.507
4mr41K0Bromodomain-containing protein 4/0.504
4a9lP9LBromodomain-containing protein 4/0.503
4a9nA9NBromodomain-containing protein 2/0.502
4bw2UTHBromodomain-containing protein 4/0.501
3zyu1GHBromodomain-containing protein 4/0.498
4bw1S5BBromodomain-containing protein 4/0.494
4lyw21QBromodomain-containing protein 4/0.494
2yemWSHBromodomain-containing protein 4/0.492
4qzsJQ1Bromodomain-containing protein 4/0.492
4j3i1K0Bromodomain-containing protein 4/0.491
4nyv15ECREB-binding protein/0.489
2yelWSHBromodomain-containing protein 4/0.487
4o78SAVBromodomain-containing protein 4/0.485
4uyg73BBromodomain-containing protein 2/0.484
4o71CPBBromodomain-containing protein 4/0.482
4hxo1A6Bromodomain-containing protein 4/0.480
4meq25OBromodomain-containing protein 4/0.480
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.479
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
4c4oNADSADH/0.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
4nr52LLCREB-binding protein/0.468
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.466
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
4bw49B6Bromodomain-containing protein 4/0.464
4f3i0S6Bromodomain-containing protein 4/0.462
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.461
4lrg1XBBromodomain-containing protein 4/0.460
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.459
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.458
2ejvNADL-threonine 3-dehydrogenase/0.457
3tqhNDPQuinone oxidoreductase/0.457
4py6R78Bromodomain protein, putative/0.457
4nyw2O3CREB-binding protein/0.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
2q59240Peroxisome proliferator-activated receptor gamma/0.455
3stv3HOMethylketone synthase I/0.455
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.454
1k7l544Peroxisome proliferator-activated receptor alpha/0.454
2xvdAS6Ephrin type-B receptor 42.7.10.10.452
3vspEK8Peroxisome proliferator-activated receptor gamma/0.452
4k9nTZDBenzoylformate decarboxylase4.1.1.70.452
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.451
3ictCOACoenzyme A disulfide reductase/0.451
3o6o94MHeat shock protein 83/0.451
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
2znq401Peroxisome proliferator-activated receptor delta/0.450
4wsqKSAAP2-associated protein kinase 12.7.11.10.450
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.449
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.449
4pzdNAD3-Hydroxyacyl-CoA dehydrogenase/0.449
1q1rFADPutidaredoxin reductase1.18.1.50.447
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.447
2ed3SAHDiphthine synthase/0.447
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
4y8wSTRSteroid 21-hydroxylase/0.446
3qlrNDPDihydrofolate reductase1.5.1.30.445
3r8814FAnthranilate phosphoribosyltransferase/0.445
4mr61K0Bromodomain-containing protein 2/0.445
3icsCOACoenzyme A disulfide reductase/0.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
1uyhPU0Heat shock protein HSP 90-alpha/0.443
2j5bTYETyrosine--tRNA ligase6.1.1.10.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1ictT44Transthyretin/0.442
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.442
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.442
4iv6FDAIsovaleryl-CoA dehydrogenase/0.442
4nb6444Nuclear receptor ROR-gamma/0.442
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1sguMK1Gag-Pol polyprotein3.4.23.160.441
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.441
1jolFFODihydrofolate reductase1.5.1.30.440
3h18PMSEsterase/lipase/0.440
3qm4PN0Cytochrome P450 2D6/0.440
4ccrFADThioredoxin reductase/0.440
4jbtASDCytochrome P450 monooxygenase/0.440
4l49CAMCamphor 5-monooxygenase1.14.15.10.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440