Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.11.000
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.723
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.611
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.610
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.604
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.582
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.572
2hog710Serine/threonine-protein kinase Chk12.7.11.10.563
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.551
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.547
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.542
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.539
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.536
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.533
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.529
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.516
5av2KMPDeath-associated protein kinase 12.7.11.10.514
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.513
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.511
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.510
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.509
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.508
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.507
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.502
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.502
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.502
2uzbC75Cyclin-dependent kinase 22.7.11.220.500
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.500
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.498
3my5RFZCyclin-dependent kinase 22.7.11.220.496
3ztxZTXAurora kinase B-A2.7.11.10.493
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.492
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.491
4ysjADPCalmodulin-like domain protein kinase/0.491
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.490
1jklANPDeath-associated protein kinase 12.7.11.10.487
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.486
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.484
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.481
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.481
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.481
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.480
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.480
4bcmT7ZCyclin-dependent kinase 22.7.11.220.478
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.478
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.477
1yvj4STTyrosine-protein kinase JAK32.7.10.20.475
4hvi19STyrosine-protein kinase JAK32.7.10.20.475
5av3KMPDeath-associated protein kinase 12.7.11.10.475
4l9i8PRRhodopsin kinase/0.473
2ckeIQUDeath-associated protein kinase 2/0.472
2j0lANPFocal adhesion kinase 12.7.10.20.472
3bqr4RBDeath-associated protein kinase 3/0.472
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.469
3eb0DRKUncharacterized protein/0.469
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.468
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.467
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.467
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.467
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
3zewSTUEphrin type-B receptor 42.7.10.10.465
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.464
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.464
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.463
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.463
4jia1K3Tyrosine-protein kinase JAK2/0.463
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.462
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.462
3c4xATPRhodopsin kinase/0.461
4ii5ADPCyclin-dependent kinase 22.7.11.220.461
1qmzATPCyclin-dependent kinase 22.7.11.220.460
3e5aVX6Aurora kinase A2.7.11.10.460
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.460
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.459
1jkkANPDeath-associated protein kinase 12.7.11.10.458
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.458
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.457
4bbfO19Tyrosine-protein kinase JAK2/0.457
3nux3NVCyclin-dependent kinase 62.7.11.220.456
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.456
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.455
4wsqKSAAP2-associated protein kinase 12.7.11.10.455
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.454
2w05FRTCyclin-dependent kinase 22.7.11.220.454
3gu7ADPDeath-associated protein kinase 12.7.11.10.454
4eooATPCyclin-dependent kinase 22.7.11.220.453
3bu5ATPInsulin receptor2.7.10.10.452
4o0wADNAurora kinase A2.7.11.10.452
5dosATPAurora kinase A2.7.11.10.452
3lpbNVBTyrosine-protein kinase JAK2/0.450
4hge15VTyrosine-protein kinase JAK2/0.450
2vu3LZECyclin-dependent kinase 22.7.11.220.449
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2j0m4STFocal adhesion kinase 12.7.10.20.448
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.448
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
2xvdAS6Ephrin type-B receptor 42.7.10.10.447
5eg3ACPFibroblast growth factor receptor 2/0.447
1finATPCyclin-dependent kinase 22.7.11.220.446
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.446
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.444
3sw719KCyclin-dependent kinase 22.7.11.220.444
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.443
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.443
3js2VM1Fibroblast growth factor receptor 1/0.443
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.443
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.442
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.442
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.442
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441