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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bus32FTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bus32FTankyrase-22.4.2.301.000
4buxF35Tankyrase-22.4.2.300.866
4l0t1V0Tankyrase-22.4.2.300.810
4bueJQFTankyrase-22.4.2.300.795
4l341VGTankyrase-22.4.2.300.757
4bs4A64Tankyrase-22.4.2.300.740
4buwF33Tankyrase-22.4.2.300.727
4l2g1V4Tankyrase-22.4.2.300.719
4kzl20DTankyrase-22.4.2.300.692
4hlm16STankyrase-22.4.2.300.663
4l0v1V1Tankyrase-22.4.2.300.661
4l2f1V3Tankyrase-22.4.2.300.656
4bj9UHBTankyrase-22.4.2.300.655
4l10A63Tankyrase-22.4.2.300.655
4iueAJ4Tankyrase-22.4.2.300.653
4hlf15ZTankyrase-22.4.2.300.647
4l33F70Tankyrase-22.4.2.300.646
4l321VFTankyrase-22.4.2.300.640
3p0pNNFTankyrase-22.4.2.300.638
4l0i1UWTankyrase-22.4.2.300.638
4hlh20DTankyrase-22.4.2.300.637
4bufF36Tankyrase-22.4.2.300.635
4bu908CTankyrase-22.4.2.300.633
4l0s1UZTankyrase-22.4.2.300.623
5aku29FTankyrase-22.4.2.300.623
3kr8XAVTankyrase-22.4.2.300.620
4hl515WTankyrase-22.4.2.300.615
4avwG18Tankyrase-22.4.2.300.611
4l2k1V8Tankyrase-22.4.2.300.606
4j22AJ7Tankyrase-22.4.2.300.598
4hkkAGITankyrase-22.4.2.300.594
4hmhF94Tankyrase-22.4.2.300.589
4hlk431Tankyrase-22.4.2.300.583
4hknLU2Tankyrase-22.4.2.300.579
4buiW2ETankyrase-22.4.2.300.571
4j21AJ6Tankyrase-22.4.2.300.571
4bud29FTankyrase-22.4.2.300.567
4hkiFLNTankyrase-22.4.2.300.566
4krs1SXTankyrase-12.4.2.300.547
4l091URTankyrase-22.4.2.300.545
4tkg09LTankyrase-22.4.2.300.543
4pnmNU1Tankyrase-22.4.2.300.530
4bjbP34Tankyrase-22.4.2.300.522
4msk2C8Tankyrase-12.4.2.300.514
4buv16ITankyrase-22.4.2.300.511
4hyf1AKTankyrase-22.4.2.300.484
4j3lAJ5Tankyrase-22.4.2.300.481
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.469
3rsv3RSBeta-secretase 13.4.23.460.465
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.465
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.463
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.462
2dshSAHDiphthine synthase/0.462
3otwCOAPhosphopantetheine adenylyltransferase/0.460
4i9i1DYTankyrase-12.4.2.300.459
4zqcF6FTryptophan synthase alpha chain/0.457
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.456
2ftoCB3Thymidylate synthase/0.454
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.453
2bbqPFGThymidylate synthase/0.452
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2bf7HBIPteridine reductase 11.5.1.330.451
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
1mueCDDProthrombin3.4.21.50.450
3tp0FO5HTH-type transcriptional regulator EthR/0.449
3tqcADPPantothenate kinase/0.448
3s55NADPutative short-chain dehydrogenase/reductase/0.447
2e7rSAHDiphthine synthase/0.446
2ejzSAHDiphthine synthase/0.446
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.446
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.445
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.445
1olmVTQSEC14-like protein 2/0.444
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1knrFADL-aspartate oxidase1.4.3.160.442
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4avuLDRTankyrase-22.4.2.300.441
4li61XOTankyrase-12.4.2.300.441
2eeqSAHDiphthine synthase/0.440
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.440
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.440
4lez1SYCyclic GMP-AMP synthase/0.440
4uxq0LIFibroblast growth factor receptor 42.7.10.10.440