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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bchT7ZCyclin-dependent kinase 92.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bchT7ZCyclin-dependent kinase 92.7.11.221.000
2vu3LZECyclin-dependent kinase 22.7.11.220.515
3blrCPBCyclin-dependent kinase 92.7.11.220.503
4bcmT7ZCyclin-dependent kinase 22.7.11.220.500
4bcqTJFCyclin-dependent kinase 22.7.11.220.500
1fvv107Cyclin-dependent kinase 22.7.11.220.499
1pkdUCNCyclin-dependent kinase 22.7.11.220.494
2uzbC75Cyclin-dependent kinase 22.7.11.220.494
4bgq38RCyclin-dependent kinase-like 52.7.11.220.493
3tnwF18Cyclin-dependent kinase 22.7.11.220.490
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.490
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.489
3nux3NVCyclin-dependent kinase 62.7.11.220.483
3pe2E1BCasein kinase II subunit alpha2.7.11.10.480
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.480
3rak03ZCyclin-dependent kinase 22.7.11.220.479
2cchATPCyclin-dependent kinase 22.7.11.220.478
2i40BLZCyclin-dependent kinase 22.7.11.220.478
3be9P04Casein kinase II subunit alpha2.7.11.10.477
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.477
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.477
2w05FRTCyclin-dependent kinase 22.7.11.220.475
3qxpX64Cyclin-dependent kinase 22.7.11.220.475
1finATPCyclin-dependent kinase 22.7.11.220.474
4grb0XGCasein kinase II subunit alpha2.7.11.10.474
2fvdLIACyclin-dependent kinase 22.7.11.220.473
2jedLG8Protein kinase C theta type2.7.11.130.473
2zjwREFCasein kinase II subunit alpha2.7.11.10.473
1g5sI17Cyclin-dependent kinase 22.7.11.220.472
2f2cAP9Cyclin-dependent kinase 62.7.11.220.471
3my5RFZCyclin-dependent kinase 22.7.11.220.471
4ogrADNCyclin-dependent kinase 92.7.11.220.471
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.468
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.466
3q9xEMOCasein kinase II subunit alpha2.7.11.10.466
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.466
2wihP48Cyclin-dependent kinase 22.7.11.220.464
3nup3NUCyclin-dependent kinase 62.7.11.220.464
3s1h56ZCyclin-dependent kinase 22.7.11.220.464
3u4uLNHCasein kinase II subunit alpha2.7.11.10.464
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.462
4eok4SPCyclin-dependent kinase 22.7.11.220.462
4ez50RSCyclin-dependent kinase 62.7.11.220.462
2uzdC85Cyclin-dependent kinase 22.7.11.220.461
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.461
2vv9IM9Cyclin-dependent kinase 22.7.11.220.460
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.460
4erwSTUCyclin-dependent kinase 22.7.11.220.460
1gih1PUCyclin-dependent kinase 22.7.11.220.459
1oiyN41Cyclin-dependent kinase 22.7.11.220.459
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.459
4fx360KCyclin-dependent kinase 22.7.11.220.459
1h1s4SPCyclin-dependent kinase 22.7.11.220.458
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.457
1pyePM1Cyclin-dependent kinase 22.7.11.220.457
3qrtX14Cyclin-dependent kinase 22.7.11.220.457
4anmWULCasein kinase II subunit alpha2.7.11.10.457
2c5nCK8Cyclin-dependent kinase 22.7.11.220.456
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.456
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.456
3e5aVX6Aurora kinase A2.7.11.10.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
3at4CCKCasein kinase II subunit alpha2.7.11.10.455
3ezvEZVCyclin-dependent kinase 22.7.11.220.455
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.454
2wxvWXVCyclin-dependent kinase 22.7.11.220.454
2x1nX1NCyclin-dependent kinase 22.7.11.220.454
3miaANPCyclin-dependent kinase 92.7.11.220.454
4eooATPCyclin-dependent kinase 22.7.11.220.453
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.453
4qmySTUSerine/threonine-protein kinase 242.7.11.10.453
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.452
4jqeANPCasein kinase II subunit alpha2.7.11.10.452
1gii1PUCyclin-dependent kinase 22.7.11.220.451
1oi9N20Cyclin-dependent kinase 22.7.11.220.451
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.451
2vtqLZACyclin-dependent kinase 22.7.11.220.451
3ddpRC8Cyclin-dependent kinase 22.7.11.220.451
3tn8F18Cyclin-dependent kinase 92.7.11.220.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
3rmf20ZCyclin-dependent kinase 22.7.11.220.450
4nj32KDCyclin-dependent kinase 22.7.11.220.450
4qo9627Serine/threonine-protein kinase 242.7.11.10.450
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.449
4eomATPCyclin-dependent kinase 22.7.11.220.449
4jvmXDIEstrogen sulfotransferase2.8.2.40.449
2wpa889Cyclin-dependent kinase 22.7.11.220.448
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.448
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.448
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.447
3axwTIDCasein kinase II subunit alpha2.7.11.10.447
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.447
4bcpT3CCyclin-dependent kinase 22.7.11.220.447
4bgg844Activin receptor type-12.7.11.300.447
2btsU32Cyclin-dependent kinase 22.7.11.220.446
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1aq1STUCyclin-dependent kinase 22.7.11.220.445
3lltANPProtein serine/threonine kinase-1/0.445
3nga3NGCasein kinase II subunit alpha2.7.11.10.445
4i22IREEpidermal growth factor receptor2.7.10.10.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
1h1r6CPCyclin-dependent kinase 22.7.11.220.444
2ckeIQUDeath-associated protein kinase 2/0.444
2j0m4STFocal adhesion kinase 12.7.10.20.444
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
3ezrEZRCyclin-dependent kinase 22.7.11.220.444
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
2pvnP63Casein kinase II subunit alpha2.7.11.10.443
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.443
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.443
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
3iw4LW4Protein kinase C alpha type2.7.11.130.442
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.442
3r9dX6BCyclin-dependent kinase 22.7.11.220.442
3rk708ZCyclin-dependent kinase 22.7.11.220.442
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
3rkb12ZCyclin-dependent kinase 22.7.11.220.441
4aguD15Cyclin-dependent kinase-like 1/0.441
2iw84SPCyclin-dependent kinase 22.7.11.220.440
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440