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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zh8C58Protein kinase C iota type2.7.11.13

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zh8C58Protein kinase C iota type2.7.11.131.000
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.498
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.482
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.478
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.475
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
1zrzBI1Protein kinase C iota type2.7.11.130.472
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.472
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.471
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.471
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.469
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.467
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.466
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.464
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.462
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.461
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.461
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.461
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.460
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.459
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.459
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
1aq1STUCyclin-dependent kinase 22.7.11.220.458
4ez50RSCyclin-dependent kinase 62.7.11.220.458
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
1eh4IC1Casein kinase I homolog 12.7.11.10.456
2in6839Wee1-like protein kinase2.7.10.20.456
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.456
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.455
2csnCKICasein kinase I homolog 12.7.11.10.455
3vs3VSETyrosine-protein kinase HCK2.7.10.20.455
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
3gu83GUDeath-associated protein kinase 12.7.11.10.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.454
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.453
1vjy460TGF-beta receptor type-12.7.11.300.453
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.453
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.453
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.452
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.452
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.452
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.451
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.451
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
1x8b824Wee1-like protein kinase2.7.10.20.449
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.449
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.449
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.448
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.448
1fvv107Cyclin-dependent kinase 22.7.11.220.447
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.446
1ykr628Cyclin-dependent kinase 22.7.11.220.445
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.445
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.445
4ji91M3Tyrosine-protein kinase JAK2/0.445
4qmpDKISerine/threonine-protein kinase 242.7.11.10.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
4y95746Tyrosine-protein kinase/0.444
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.443
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
2w17I19Cyclin-dependent kinase 22.7.11.220.442
3ezvEZVCyclin-dependent kinase 22.7.11.220.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.442
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3eyhIZATyrosine-protein kinase JAK1/0.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3rak03ZCyclin-dependent kinase 22.7.11.220.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.440