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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3poz03PEpidermal growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3poz03PEpidermal growth factor receptor2.7.10.11.000
3w32W32Epidermal growth factor receptor2.7.10.10.666
3w33W19Epidermal growth factor receptor2.7.10.10.653
1xkkFMMEpidermal growth factor receptor2.7.10.10.602
3w2sW2REpidermal growth factor receptor2.7.10.10.570
3vs3VSETyrosine-protein kinase HCK2.7.10.20.546
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.537
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.527
4i22IREEpidermal growth factor receptor2.7.10.10.513
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.510
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.510
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.497
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.496
3tqhNDPQuinone oxidoreductase/0.495
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.494
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.493
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.493
2wotZZGTGF-beta receptor type-12.7.11.300.485
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.479
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.477
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.475
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.474
3ogqAB1Pol polyprotein/0.472
4hgs15GCasein kinase I isoform gamma-32.7.11.10.472
3vt7VDXVitamin D3 receptor/0.471
3vryB43Tyrosine-protein kinase HCK2.7.10.20.470
3vt9YI4Vitamin D3 receptor/0.470
3q43D66M1 family aminopeptidase3.4.110.469
5br4NADLactaldehyde reductase1.1.1.770.469
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.467
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
1sn5T3Transthyretin/0.466
2po7CHDFerrochelatase, mitochondrial4.99.1.10.466
3sp9IL2Peroxisome proliferator-activated receptor delta/0.466
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.464
2znq401Peroxisome proliferator-activated receptor delta/0.464
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.464
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.463
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.463
4tuvCPZCytochrome P450 1191.140.463
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
2y3rTRKTamL/0.460
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.460
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.459
4id71G0Activated CDC42 kinase 1/0.458
4nxuADPMitochondrial dynamics protein MID51/0.458
3oroAGSSerine/threonine protein kinase/0.457
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.457
4wkqIREEpidermal growth factor receptor2.7.10.10.457
3ctj320Hepatocyte growth factor receptor2.7.10.10.456
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.456
3oev3OEProteasome subunit beta type-53.4.25.10.456
3oev3OEProteasome subunit beta type-63.4.25.10.456
4k2xFADPolyketide oxygenase/hydroxylase/0.456
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2gjlFMNNitronate monooxygenase1.13.12.160.455
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.455
1tw4CHDFatty acid-binding protein, liver/0.454
1u54ACPActivated CDC42 kinase 1/0.454
4xiwAZMCarbonic anhydrase, alpha type/0.454
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.454
1jipKTN6-deoxyerythronolide B hydroxylase/0.453
2znnS44Peroxisome proliferator-activated receptor alpha/0.453
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.453
4hjoAQ4Epidermal growth factor receptor2.7.10.10.453
4ipw1G7Mycocyclosin synthase1.14.21.90.453
1k6pXN3Gag-Pol polyprotein3.4.23.160.452
2gjnFMNNitronate monooxygenase1.13.12.160.452
4a28ADPKinesin-like protein KIF11/0.452
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.452
4dfrMTXDihydrofolate reductase1.5.1.30.452
4riyADPEpidermal growth factor receptor2.7.10.10.452
1ie8KH1Vitamin D3 receptor/0.451
2hw2RFPRifampin ADP-ribosyl transferase/0.451
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2p33J07Mitogen-activated protein kinase 102.7.11.240.450
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.450
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
4y93746Tyrosine-protein kinase/0.450
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
1tz8DESTransthyretin/0.449
2rhrEMOPutative ketoacyl reductase1.3.10.449
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.449
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.449
3k4nFADPyranose 2-oxidase/0.449
3l9hEMQKinesin-like protein KIF11/0.449
4o2bLOCTubulin beta-2B chain/0.449
5k2aZMAAdenosine receptor A2a/0.449
2om9AJAPeroxisome proliferator-activated receptor gamma/0.448
3csdEMOPutative ketoacyl reductase1.3.10.448
3ormAGSSerine/threonine protein kinase/0.448
3vt8YI3Vitamin D3 receptor/0.448
4q71FADBifunctional protein PutA/0.448
4xgxADPFAD:protein FMN transferase/0.448
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1pmn984Mitogen-activated protein kinase 102.7.11.240.447
1s0zEB1Vitamin D3 receptor/0.447
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.447
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.447
3hv5R24Mitogen-activated protein kinase 14/0.447
3zuyTCHTransporter/0.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4dc0NDPPutative ketoacyl reductase1.3.10.447
4nka2K7Fibroblast growth factor receptor 1/0.447
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.447
1u4dDBQActivated CDC42 kinase 1/0.446
2ca0PXICytochrome P450 monooxygenase PikC/0.446
2j5xGSPADP-ribosylation factor 6/0.446
3icrFADCoenzyme A disulfide reductase/0.446
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.446
4a6bQG8Gag-Pol polyprotein3.4.23.160.446
4y95746Tyrosine-protein kinase/0.446
1eupASD6-deoxyerythronolide B hydroxylase/0.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.445
2q5p241Peroxisome proliferator-activated receptor gamma/0.445
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.445
4fhi0S4Vitamin D3 receptor A/0.445
4jazSTLPeroxisome proliferator-activated receptor gamma/0.445
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.444
1kkq471Peroxisome proliferator-activated receptor alpha/0.444
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.444
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
2fzkCTPAspartate carbamoyltransferase regulatory chain/0.444
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.444
3rj5NADAlcohol dehydrogenase1.1.1.10.444
3w0yDS4Vitamin D3 receptor/0.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.444
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.444
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
4l4cCAMCamphor 5-monooxygenase1.14.15.10.444
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
5k2cZMAAdenosine receptor A2a/0.444
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.443
2p4yC03Peroxisome proliferator-activated receptor gamma/0.443
2pobGW4Peroxisome proliferator-activated receptor gamma/0.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.443
3fwfCAMCamphor 5-monooxygenase1.14.15.10.443
3icsADPCoenzyme A disulfide reductase/0.443
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.443
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.443
4ienCOAPutative acyl-CoA hydrolase/0.443
1q1rFADPutidaredoxin reductase1.18.1.50.442
1yb5NAPQuinone oxidoreductase1.6.5.50.442
1zhwHC2Oxysterol-binding protein homolog 4/0.442
2ahrNAPPyrroline-5-carboxylate reductase/0.442
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2uxoTACHTH-type transcriptional regulator TtgR/0.442
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.442
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.442
3gwfFADCyclohexanone monooxygenase/0.442
3oriAGSSerine/threonine protein kinase/0.442
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.442
3w5rLOAVitamin D3 receptor/0.442
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.442
4m11MXMProstaglandin G/H synthase 21.14.99.10.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.442
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3v9v21LPeroxisome proliferator-activated receptor gamma/0.441
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4b7sQLECytochrome P450 monooxygenase PikC/0.441
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.441
4kwi1TJReductase homolog/0.441
4q73FADBifunctional protein PutA/0.441
5fkmTDCTetracycline repressor protein class D/0.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1diuBDMDihydrofolate reductase1.5.1.30.440
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.440
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2harOCCVitamin D3 receptor/0.440
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.440
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.440
2w1fL0FAurora kinase A2.7.11.10.440
3nbzGTPGTP-binding nuclear protein Ran/0.440
3nr4PYVAbscisic acid receptor PYL2/0.440
3r9oZ71Cyclin-dependent kinase 22.7.11.220.440
3v9y24LPeroxisome proliferator-activated receptor gamma/0.440
3vspEK8Peroxisome proliferator-activated receptor gamma/0.440
3zuxTCHTransporter/0.440
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4g48PZBMycocyclosin synthase1.14.21.90.440