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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.626
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.619
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.593
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.585
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.570
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.562
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.525
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.507
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.499
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.479
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.472
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.469
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.468
3lltANPProtein serine/threonine kinase-1/0.468
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.467
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.463
4bcmT7ZCyclin-dependent kinase 22.7.11.220.462
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.460
2etrY27Rho-associated protein kinase 12.7.11.10.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
1jklANPDeath-associated protein kinase 12.7.11.10.458
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.457
2uzbC75Cyclin-dependent kinase 22.7.11.220.456
4ic7ANPMitogen-activated protein kinase 72.7.11.240.456
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4fv9E71Mitogen-activated protein kinase 12.7.11.240.453
4ysjADPCalmodulin-like domain protein kinase/0.453
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
5av2KMPDeath-associated protein kinase 12.7.11.10.451
2vu3LZECyclin-dependent kinase 22.7.11.220.449
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.448
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4dgmAGICasein kinase II subunit alpha2.7.11.10.448
4l9i8PRRhodopsin kinase/0.448
2f2uM77Rho-associated protein kinase 22.7.11.10.447
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.447
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
5e8ySTUTGF-beta receptor type-22.7.11.300.447
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
1qmzATPCyclin-dependent kinase 22.7.11.220.445
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.444
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.442
2ijmADPFocal adhesion kinase 12.7.10.20.441
2yaaATPDeath-associated protein kinase 2/0.440