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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3my5RFZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3my5RFZCyclin-dependent kinase 22.7.11.221.000
4bcmT7ZCyclin-dependent kinase 22.7.11.220.572
1qmzATPCyclin-dependent kinase 22.7.11.220.549
2uzbC75Cyclin-dependent kinase 22.7.11.220.519
4eooATPCyclin-dependent kinase 22.7.11.220.509
2cjmATPCyclin-dependent kinase 22.7.11.220.501
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4ii5ADPCyclin-dependent kinase 22.7.11.220.491
3i60E86Mitogen-activated protein kinase 12.7.11.240.490
2vu3LZECyclin-dependent kinase 22.7.11.220.487
2ckeIQUDeath-associated protein kinase 2/0.481
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.480
4i3zADPCyclin-dependent kinase 22.7.11.220.477
2fvdLIACyclin-dependent kinase 22.7.11.220.471
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4ysjADPCalmodulin-like domain protein kinase/0.470
3s1h56ZCyclin-dependent kinase 22.7.11.220.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.464
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.463
1gii1PUCyclin-dependent kinase 22.7.11.220.462
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
5av2KMPDeath-associated protein kinase 12.7.11.10.459
4qnyANPMitogen activated protein kinase, putative/0.458
1ig1ANPDeath-associated protein kinase 12.7.11.10.457
3ztxZTXAurora kinase B-A2.7.11.10.457
2vv9IM9Cyclin-dependent kinase 22.7.11.220.454
3rak03ZCyclin-dependent kinase 22.7.11.220.454
2w4jADPDeath-associated protein kinase 12.7.11.10.451
3c4wATPRhodopsin kinase/0.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
1fvv107Cyclin-dependent kinase 22.7.11.220.450
2yaaATPDeath-associated protein kinase 2/0.450
2uzdC85Cyclin-dependent kinase 22.7.11.220.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.449
3r8lZ30Cyclin-dependent kinase 22.7.11.220.449
3sw719KCyclin-dependent kinase 22.7.11.220.449
4fv6E57Mitogen-activated protein kinase 12.7.11.240.449
1finATPCyclin-dependent kinase 22.7.11.220.447
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.447
2w05FRTCyclin-dependent kinase 22.7.11.220.446
1pxmCK5Cyclin-dependent kinase 22.7.11.220.445
3lltANPProtein serine/threonine kinase-1/0.445
3nux3NVCyclin-dependent kinase 62.7.11.220.445
1w8cN69Cyclin-dependent kinase 22.7.11.220.444
3rkb12ZCyclin-dependent kinase 22.7.11.220.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
1jstATPCyclin-dependent kinase 22.7.11.220.443
3c4xATPRhodopsin kinase/0.443
3qxpX64Cyclin-dependent kinase 22.7.11.220.443
4jia1K3Tyrosine-protein kinase JAK2/0.443
5ap7SVEDual specificity protein kinase TTK2.7.12.10.443
2c6lDT4Cyclin-dependent kinase 22.7.11.220.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
3qzgX67Cyclin-dependent kinase 22.7.11.220.440