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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.644
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.626
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.600
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.590
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.566
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.560
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.556
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.539
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.496
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2f2uM77Rho-associated protein kinase 22.7.11.10.483
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.474
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2yaaATPDeath-associated protein kinase 2/0.470
2etrY27Rho-associated protein kinase 12.7.11.10.468
3ncz3NCRho-associated protein kinase 12.7.11.10.467
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
1jklANPDeath-associated protein kinase 12.7.11.10.465
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.463
4fv6E57Mitogen-activated protein kinase 12.7.11.240.463
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.457
5av2KMPDeath-associated protein kinase 12.7.11.10.457
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.456
4o0wADNAurora kinase A2.7.11.10.456
5dt0SKEAurora kinase A2.7.11.10.456
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.454
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.452
5aut2ANDeath-associated protein kinase 12.7.11.10.451
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3bqr4RBDeath-associated protein kinase 3/0.450
3lltANPProtein serine/threonine kinase-1/0.449
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.449
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.448
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3i60E86Mitogen-activated protein kinase 12.7.11.240.447
5dpvSKEAurora kinase A2.7.11.10.447
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3juhANPCasein kinase II subunit alpha2.7.11.10.440
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.440