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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wqeADPAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wqeADPAurora kinase A2.7.11.11.000
5l8lADPAurora kinase A2.7.11.10.598
4o0uADNAurora kinase A2.7.11.10.596
3k5uPFQAurora kinase A2.7.11.10.565
4c3pACPAurora kinase A2.7.11.10.565
2c6eHPMAurora kinase A2.7.11.10.551
4jbpYPHAurora kinase A2.7.11.10.513
4jbqVX6Aurora kinase A2.7.11.10.513
4b0gVEKAurora kinase A2.7.11.10.511
3w18N13Aurora kinase A2.7.11.10.502
3ztxZTXAurora kinase B-A2.7.11.10.496
2ijmATPFocal adhesion kinase 12.7.10.20.485
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.483
4jboWPHAurora kinase A2.7.11.10.483
4qmlANPSerine/threonine-protein kinase 242.7.11.10.482
4deeADPAurora kinase A2.7.11.10.479
2bmcMPYAurora kinase A2.7.11.10.476
3ttjJBIMitogen-activated protein kinase 102.7.11.240.469
2qo7ANPEphrin type-A receptor 32.7.10.10.468
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.466
5ap7SVEDual specificity protein kinase TTK2.7.12.10.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.463
4c4f7CEDual specificity protein kinase TTK2.7.12.10.463
2w1fL0FAurora kinase A2.7.11.10.462
1i44ACPInsulin receptor2.7.10.10.460
3erkSB4Mitogen-activated protein kinase 12.7.11.240.460
3c4xATPRhodopsin kinase/0.459
2zmd537Dual specificity protein kinase TTK2.7.12.10.458
2j0lANPFocal adhesion kinase 12.7.10.20.457
4l9i8PRRhodopsin kinase/0.457
2qoqANPEphrin type-A receptor 32.7.10.10.456
3efwAK8Aurora kinase A2.7.11.10.456
4c3rACPAurora kinase A2.7.11.10.455
4k8aK8AFocal adhesion kinase 12.7.10.20.455
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
2vgpAD6Aurora kinase B-A2.7.11.10.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
5dosATPAurora kinase A2.7.11.10.452
3c4zADPRhodopsin kinase/0.450
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
5ap57RODual specificity protein kinase TTK2.7.12.10.450
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.448
2henADPEphrin type-B receptor 22.7.10.10.447
5awmANPStress-activated protein kinase JNK2.7.11.240.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.444
3c4wATPRhodopsin kinase/0.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.443
4eym0RXMitogen-activated protein kinase 132.7.11.240.443
5dt3ATPAurora kinase A2.7.11.10.443
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.442
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.442
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.441
3l8p0CEAngiopoietin-1 receptor2.7.10.10.441
3qc9ADPRhodopsin kinase/0.441
3t8oATPRhodopsin kinase/0.441
3oriAGSSerine/threonine protein kinase/0.440
3orpAGSSerine/threonine protein kinase/0.440
4o0wADNAurora kinase A2.7.11.10.440