scPDB - Distribution of Cavity Similarity values of 2pzn entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2pzn	393	Aldose reductase	1.1.1.21

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2pzn	393	Aldose reductase	1.1.1.21	1.000
1z3n	3NA	Aldose reductase	1.1.1.21	0.673
3g5e	Q74	Aldose reductase	1.1.1.21	0.665
2i16	LDT	Aldose reductase	1.1.1.21	0.648
3ghu	LDT	Aldose reductase	1.1.1.21	0.640
2fz8	ZST	Aldose reductase	1.1.1.21	0.636
3mb9	ZST	Aldose reductase	1.1.1.21	0.636
2i17	LDT	Aldose reductase	1.1.1.21	0.635
2dv0	ZST	Aldose reductase	1.1.1.21	0.632
2hvo	ZST	Aldose reductase	1.1.1.21	0.630
2pdp	393	Aldose reductase	1.1.1.21	0.628
3ghr	LDT	Aldose reductase	1.1.1.21	0.628
1pwl	BFI	Aldose reductase	1.1.1.21	0.626
2qxw	LDT	Aldose reductase	1.1.1.21	0.625
3ghs	LDT	Aldose reductase	1.1.1.21	0.620
2dux	ZST	Aldose reductase	1.1.1.21	0.619
2pd5	ZST	Aldose reductase	1.1.1.21	0.619
1t40	ID5	Aldose reductase	1.1.1.21	0.618
1us0	LDT	Aldose reductase	1.1.1.21	0.618
2hv5	ZST	Aldose reductase	1.1.1.21	0.617
2duz	ZST	Aldose reductase	1.1.1.21	0.616
2pdx	ZST	Aldose reductase	1.1.1.21	0.614
3ld5	LDT	Aldose reductase	1.1.1.21	0.609
2fz9	ZST	Aldose reductase	1.1.1.21	0.606
3ght	LDT	Aldose reductase	1.1.1.21	0.606
2pdc	393	Aldose reductase	1.1.1.21	0.604
2pdh	47D	Aldose reductase	1.1.1.21	0.604
2pdu	393	Aldose reductase	1.1.1.21	0.602
2ikj	393	Aldose reductase	1.1.1.21	0.598
3lbo	LDT	Aldose reductase	1.1.1.21	0.596
3t42	3T4	Aldose reductase	1.1.1.21	0.593
1z89	62P	Aldose reductase	1.1.1.21	0.590
2pdb	ZST	Aldose reductase	1.1.1.21	0.589
2pdf	ZST	Aldose reductase	1.1.1.21	0.586
2pdg	47D	Aldose reductase	1.1.1.21	0.586
3len	ZST	Aldose reductase	1.1.1.21	0.586
4yu1	53N	Aldose reductase	1.1.1.21	0.581
3mc5	393	Aldose reductase	1.1.1.21	0.579
2iki	388	Aldose reductase	1.1.1.21	0.578
3m64	393	Aldose reductase	1.1.1.21	0.576
2pdl	TOL	Aldose reductase	1.1.1.21	0.573
4gca	2X9	Aldose reductase	1.1.1.21	0.573
3m4h	388	Aldose reductase	1.1.1.21	0.562
3lql	LDT	Aldose reductase	1.1.1.21	0.561
1t41	ID5	Aldose reductase	1.1.1.21	0.560
2pdn	47D	Aldose reductase	1.1.1.21	0.556
1frb	ZST	Aldose reductase-related protein 2	/	0.553
3m0i	ZST	Aldose reductase	1.1.1.21	0.552
3lz5	LDT	Aldose reductase	1.1.1.21	0.549
2fzd	TOL	Aldose reductase	1.1.1.21	0.534
2ikh	LIT	Aldose reductase	1.1.1.21	0.533
1ah3	TOL	Aldose reductase	1.1.1.21	0.529
1iei	ZES	Aldose reductase	1.1.1.21	0.529
2pdq	47D	Aldose reductase	1.1.1.21	0.529
2pdj	393	Aldose reductase	1.1.1.21	0.528
2f2k	TGG	Aldose reductase	1.1.1.21	0.489
2fzb	TOL	Aldose reductase	1.1.1.21	0.484
2agt	FID	Aldose reductase	1.1.1.21	0.478
2pdy	FID	Aldose reductase	1.1.1.21	0.471
2iqd	LPA	Aldose reductase	1.1.1.21	0.467
4dbw	511	Aldo-keto reductase family 1 member C3	/	0.467
2v0m	KLN	Cytochrome P450 3A4	/	0.466
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.465
3wav	DWV	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	3.1.4.39	0.465
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.465
4k4e	K4E	Tankyrase-1	2.4.2.30	0.463
1o5r	FR9	Adenosine deaminase	3.5.4.4	0.461
2inz	OHP	Aldose reductase	1.1.1.21	0.461
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.458
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.456
1tbb	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.455
1q83	TZ5	Acetylcholinesterase	3.1.1.7	0.454
2aot	SAH	Histamine N-methyltransferase	2.1.1.8	0.454
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.454
3aiq	HBO	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic	3.2.1.182	0.453
3p2v	DOY	Aldose reductase	1.1.1.21	0.453
5std	UNN	Scytalone dehydratase	4.2.1.94	0.453
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.452
2ckm	AA7	Acetylcholinesterase	3.1.1.7	0.451
2xuj	TZ5	Acetylcholinesterase	3.1.1.7	0.450
1h22	E10	Acetylcholinesterase	3.1.1.7	0.448
3aiv	HBO	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	3.2.1.182	0.448
3u8d	U8D	Phospholipase A2, membrane associated	/	0.447
1el3	I84	Aldose reductase	1.1.1.21	0.446
1gt5	BZQ	Odorant-binding protein	/	0.445
2xuh	TZ4	Acetylcholinesterase	3.1.1.7	0.445
3e4v	FMN	Uncharacterized protein	/	0.445
4ajd	F04	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.445
4d2d	ALA_ALA_ALA	Di-or tripeptide:H+ symporter	/	0.445
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.444
2ga2	A19	Methionine aminopeptidase 2	/	0.443
2j3q	TFL	Acetylcholinesterase	3.1.1.7	0.443
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.443
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.443
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.443
3sn6	P0G	Beta-2 adrenergic receptor	/	0.443
1ah0	SBI	Aldose reductase	1.1.1.21	0.442
2cbq	TH2	Neocarzinostatin	/	0.442
2pdk	SBI	Aldose reductase	1.1.1.21	0.442
3c3x	NAP	Eugenol synthase 1	1.1.1.318	0.442
3f3y	4OA	Bile salt sulfotransferase	2.8.2.14	0.442
4gab	FID	Aldo-keto reductase family 1 member B10	1.1.1	0.442
4mt9	2D6	Tankyrase-1	2.4.2.30	0.442
1ro6	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.441
3iak	EV1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
1zgc	A2E	Acetylcholinesterase	3.1.1.7	0.440