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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.261.000
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.599
2i0ePDSProtein kinase C beta type2.7.11.130.567
2jedLG8Protein kinase C theta type2.7.11.130.553
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.548
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.546
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.541
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.539
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.526
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.526
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.525
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.523
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.519
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.519
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.512
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.511
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.507
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.504
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.503
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.498
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.498
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.492
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.492
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.490
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.488
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.488
4bchT7ZCyclin-dependent kinase 92.7.11.220.487
3du8553Glycogen synthase kinase-3 beta2.7.11.260.486
4othDRNSerine/threonine-protein kinase N1/0.482
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.481
3iw4LW4Protein kinase C alpha type2.7.11.130.478
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.476
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.474
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.472
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.472
4qms1N1Serine/threonine-protein kinase 242.7.11.10.471
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.469
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.469
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.468
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.468
1kkq471Peroxisome proliferator-activated receptor alpha/0.467
3a1l2CCCytochrome P450/0.467
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.467
4ykfFADAlkyl hydroperoxide reductase subunit F1.8.10.465
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.462
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
3vf9477Tyrosine-protein kinase SYK2.7.10.20.460
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.459
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.458
3a60STURibosomal protein S6 kinase beta-12.7.11.10.458
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.458
4hvh19RTyrosine-protein kinase JAK32.7.10.20.458
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
2itqITQEpidermal growth factor receptor2.7.10.10.455
4ewqMWLMitogen-activated protein kinase 14/0.455
4jrvKJVEpidermal growth factor receptor2.7.10.10.455
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.454
2xikJ60Serine/threonine-protein kinase 252.7.11.10.454
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.454
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.453
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1bk0ACVIsopenicillin N synthase1.21.3.10.452
4ug7H4BNitric oxide synthase oxygenase1.14.13.1650.452
3reyXACAdenosine receptor A2a/0.452
1m9tH4BNitric oxide synthase, inducible1.14.13.390.451
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.451
4i22IREEpidermal growth factor receptor2.7.10.10.451
2c475IDCasein kinase I isoform gamma-2/0.450
3gc8B45Mitogen-activated protein kinase 112.7.11.240.450
1phgMYTCamphor 5-monooxygenase1.14.15.10.449
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.449
2uxoTACHTH-type transcriptional regulator TtgR/0.449
3slkNDPPolyketide synthase extender module 2/0.449
4wboANWRhodopsin kinase/0.449
2iviACWIsopenicillin N synthase1.21.3.10.448
2uxuNARHTH-type transcriptional regulator TtgR/0.448
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1jpaANPEphrin type-B receptor 22.7.10.10.447
3fmn530Mitogen-activated protein kinase 14/0.447
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
5dp2NAPCurF/0.447
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4qa2SHHHistone deacetylase 83.5.1.980.446
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.445
3otwCOAPhosphopantetheine adenylyltransferase/0.445
4lopSB4Mitogen-activated protein kinase 14/0.445
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.445
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1pjcNADAlanine dehydrogenase/0.444
3dt1P40Mitogen-activated protein kinase 14/0.444
3e5aVX6Aurora kinase A2.7.11.10.444
3gc9B45Mitogen-activated protein kinase 112.7.11.240.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.444
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.444
3hl7I47Mitogen-activated protein kinase 14/0.443
3kytHC2Nuclear receptor ROR-gamma/0.443
4c9pCAMCytochrome P450/0.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
1nhhANPDNA mismatch repair protein MutL/0.442
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.442
2znq401Peroxisome proliferator-activated receptor delta/0.442
3l8p0CEAngiopoietin-1 receptor2.7.10.10.442
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.442
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.442
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.442
4nj32KDCyclin-dependent kinase 22.7.11.220.442
4o5qFADAlkyl hydroperoxide reductase subunit F1.8.10.442
1m9jCLWNitric oxide synthase, endothelial1.14.13.390.441
1t2cNAIL-lactate dehydrogenase1.1.1.270.441
4js9H4BNitric oxide synthase, inducible1.14.13.390.441
2ghlLIBMitogen-activated protein kinase 14/0.440
2vrbNAPTriphenylmethane reductase/0.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3hl0NADMaleylacetate reductase/0.440
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.440