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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ojj82AMitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ojj82AMitogen-activated protein kinase 12.7.11.241.000
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.562
4gt3ATPMitogen-activated protein kinase 12.7.11.240.559
4fv9E71Mitogen-activated protein kinase 12.7.11.240.547
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.541
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.526
4b99R4LMitogen-activated protein kinase 72.7.11.240.510
4s33ANPMitogen-activated protein kinase 12.7.11.240.509
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4ic7ANPMitogen-activated protein kinase 72.7.11.240.496
3i60E86Mitogen-activated protein kinase 12.7.11.240.489
4fuxE75Mitogen-activated protein kinase 12.7.11.240.486
4fv6E57Mitogen-activated protein kinase 12.7.11.240.486
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.484
3c4xATPRhodopsin kinase/0.483
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.481
4l9i8PRRhodopsin kinase/0.481
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
4bcmT7ZCyclin-dependent kinase 22.7.11.220.480
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.479
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.478
3erkSB4Mitogen-activated protein kinase 12.7.11.240.475
3ztxZTXAurora kinase B-A2.7.11.10.469
2x9fX9FEphrin type-B receptor 42.7.10.10.468
3my5RFZCyclin-dependent kinase 22.7.11.220.468
4s34ANPMitogen-activated protein kinase 12.7.11.240.468
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.467
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4h3qANPMitogen-activated protein kinase 12.7.11.240.466
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.464
2f2uM77Rho-associated protein kinase 22.7.11.10.462
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.459
4aguD15Cyclin-dependent kinase-like 1/0.459
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
2yaaATPDeath-associated protein kinase 2/0.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
5av2KMPDeath-associated protein kinase 12.7.11.10.457
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.456
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3bqr4RBDeath-associated protein kinase 3/0.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
2xvdAS6Ephrin type-B receptor 42.7.10.10.452
3c4wATPRhodopsin kinase/0.452
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.450
1tvoFRZMitogen-activated protein kinase 12.7.11.240.449
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.448
4fmqANPMitogen-activated protein kinase 12.7.11.240.448
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.446
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3qc9ADPRhodopsin kinase/0.445
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3sa0NRAMitogen-activated protein kinase 12.7.11.240.442
4qnyANPMitogen activated protein kinase, putative/0.442
5ap7SVEDual specificity protein kinase TTK2.7.12.10.442
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3w2sW2REpidermal growth factor receptor2.7.10.10.441
4c3pACPAurora kinase A2.7.11.10.441
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.440
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.440