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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itpAEEEpidermal growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2itpAEEEpidermal growth factor receptor2.7.10.11.000
2ittAEEEpidermal growth factor receptor2.7.10.10.589
4jq8KJ8Epidermal growth factor receptor2.7.10.10.584
1m17AQ4Epidermal growth factor receptor2.7.10.10.580
2itxANPEpidermal growth factor receptor2.7.10.10.577
4jq7KJQEpidermal growth factor receptor2.7.10.10.577
4jrvKJVEpidermal growth factor receptor2.7.10.10.571
2itnANPEpidermal growth factor receptor2.7.10.10.569
2itwITQEpidermal growth factor receptor2.7.10.10.555
4jr3KJREpidermal growth factor receptor2.7.10.10.544
2itqITQEpidermal growth factor receptor2.7.10.10.532
4wkqIREEpidermal growth factor receptor2.7.10.10.518
3w33W19Epidermal growth factor receptor2.7.10.10.509
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.508
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.508
3w2sW2REpidermal growth factor receptor2.7.10.10.508
4c02TAKActivin receptor type-12.7.11.300.503
2itvANPEpidermal growth factor receptor2.7.10.10.500
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.498
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
4riyADPEpidermal growth factor receptor2.7.10.10.494
4i231C9Epidermal growth factor receptor2.7.10.10.493
3vjoANPEpidermal growth factor receptor2.7.10.10.489
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2ituITQEpidermal growth factor receptor2.7.10.10.488
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.484
4hjoAQ4Epidermal growth factor receptor2.7.10.10.484
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.483
4i22IREEpidermal growth factor receptor2.7.10.10.483
1eh4IC1Casein kinase I homolog 12.7.11.10.482
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.482
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.480
1xkkFMMEpidermal growth factor receptor2.7.10.10.479
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.478
2of2547Tyrosine-protein kinase Lck2.7.10.20.478
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.477
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
2y6o1N1Ephrin type-A receptor 42.7.10.10.476
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.475
2eb3ANPEpidermal growth factor receptor2.7.10.10.474
1py5PY1TGF-beta receptor type-12.7.11.300.473
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.473
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
4dymIYZActivin receptor type-12.7.11.300.470
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.470
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.470
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.468
4nks2M2Fibroblast growth factor receptor 1/0.468
1bygSTUTyrosine-protein kinase CSK/0.467
1ywrLI9Mitogen-activated protein kinase 14/0.467
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.467
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.466
3a62STURibosomal protein S6 kinase beta-12.7.11.10.465
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.465
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.465
5aacVGHALK tyrosine kinase receptor2.7.10.10.465
2itzIREEpidermal growth factor receptor2.7.10.10.464
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.464
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.463
3mtfA3FActivin receptor type-12.7.11.300.463
4hvh19RTyrosine-protein kinase JAK32.7.10.20.462
1vjy460TGF-beta receptor type-12.7.11.300.461
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.461
2of4979Tyrosine-protein kinase Lck2.7.10.20.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
2j0k4STFocal adhesion kinase 12.7.10.20.459
2j7t274Serine/threonine-protein kinase 102.7.11.10.459
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.459
4gk3L87Ephrin type-A receptor 32.7.10.10.459
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.458
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.458
4qnaX11Serine/threonine-protein kinase 242.7.11.10.458
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
4y95746Tyrosine-protein kinase/0.456
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.456
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.454
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.454
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.453
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2i0ePDSProtein kinase C beta type2.7.11.130.453
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.453
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.453
3vjnANPEpidermal growth factor receptor2.7.10.10.453
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4j97ACPFibroblast growth factor receptor 2/0.453
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.452
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.452
3fklFKLMitogen-activated protein kinase 14/0.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.452
4fob0USALK tyrosine kinase receptor2.7.10.10.452
4y93746Tyrosine-protein kinase/0.452
3hmm855TGF-beta receptor type-12.7.11.300.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.451
4grb0XGCasein kinase II subunit alpha2.7.11.10.451
4hvg19QTyrosine-protein kinase JAK32.7.10.20.451
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.451
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
2ijmADPFocal adhesion kinase 12.7.10.20.450
3dt1P40Mitogen-activated protein kinase 14/0.449
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.449
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.449
4gk2L66Ephrin type-A receptor 32.7.10.10.449
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.449
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.449
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.448
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.448
4c62XWWTyrosine-protein kinase JAK2/0.448
4f630S7Fibroblast growth factor receptor 1/0.448
4ienCOAPutative acyl-CoA hydrolase/0.448
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.447
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.447
4kbk1QGCasein kinase I isoform delta2.7.11.10.447
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.446
2xyuQ9GEphrin type-A receptor 42.7.10.10.446
3gobHXXDdmC/0.446
3w32W32Epidermal growth factor receptor2.7.10.10.446
4nka2K7Fibroblast growth factor receptor 1/0.446
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.446
1ay0TPPTransketolase 12.2.1.10.445
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.445
2vwu7X1Ephrin type-B receptor 42.7.10.10.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1u54ACPActivated CDC42 kinase 1/0.444
2pwlACPFibroblast growth factor receptor 2/0.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
3js2VM1Fibroblast growth factor receptor 1/0.444
4aa5NQBMitogen-activated protein kinase 14/0.444
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1xl2189Gag-Pol polyprotein3.4.23.160.443
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.443
4fnzNZFALK tyrosine kinase receptor2.7.10.10.443
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.443
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.443
5aaaVGHALK tyrosine kinase receptor2.7.10.10.443
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.442
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.442
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.442
3flwFLWMitogen-activated protein kinase 14/0.442
3poz03PEpidermal growth factor receptor2.7.10.10.442
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.442
3sp9IL2Peroxisome proliferator-activated receptor delta/0.442
3uyt0CKCasein kinase I isoform delta2.7.11.10.442
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.441
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.441
3emg685Tyrosine-protein kinase SYK2.7.10.20.441
3uvqFS8Mitogen-activated protein kinase 14/0.441
4j98ACPFibroblast growth factor receptor 2/0.441
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.441
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.441
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.440
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.440
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.440