sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 | 1.000 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.692 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.531 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.523 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.518 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.518 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.517 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.515 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.515 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.513 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.512 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.511 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.509 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.509 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.508 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.506 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.504 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.503 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.503 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.503 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.503 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.501 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.501 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.500 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.499 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.492 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.492 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.491 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.489 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.486 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.485 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.484 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.479 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.478 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.477 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.476 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.476 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.474 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.473 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.473 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.470 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.470 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.467 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.465 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.464 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.463 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.462 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.459 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.459 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.457 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.456 | |
| 3wec | AUI | Cytochrome P450 | / | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.454 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.453 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.449 | |
| 1ppj | ANY | Cytochrome b | / | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.443 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.443 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.440 |