sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1pzg | A3D | Lactate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1pzg | A3D | Lactate dehydrogenase | / | 1.000 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.689 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.628 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.622 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.618 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.614 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.602 | |
| 2hjr | APR | Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase | / | 0.592 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.568 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.562 | |
| 5mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.560 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.545 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.541 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.540 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.537 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.533 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.523 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.505 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.504 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.493 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.492 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.492 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.489 | |
| 4al4 | W7E | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.484 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.481 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.477 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.475 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.472 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.472 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.471 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.470 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 2jhf | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.468 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.467 | |
| 1adb | CND | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 4dwv | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 1r37 | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.462 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.462 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.462 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.461 | |
| 4c4o | NAD | SADH | / | 0.461 | |
| 4ng5 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.460 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 1a71 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.457 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.457 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.455 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.455 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.454 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.454 | |
| 4w6z | 8ID | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.453 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.452 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.450 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.449 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.447 | |
| 1agn | NAD | Alcohol dehydrogenase class 4 mu/sigma chain | 1.1.1.1 | 0.446 | |
| 1hsz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.446 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.446 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.446 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.445 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.444 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.441 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.440 |