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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pxoCK7Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pxoCK7Cyclin-dependent kinase 22.7.11.221.000
2btrU73Cyclin-dependent kinase 22.7.11.220.550
2btsU32Cyclin-dependent kinase 22.7.11.220.545
4bgh3I6Cyclin-dependent kinase 22.7.11.220.537
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.533
3r1yX76Cyclin-dependent kinase 22.7.11.220.531
3lfnA27Cyclin-dependent kinase 22.7.11.220.528
4fki09KCyclin-dependent kinase 22.7.11.220.527
3s1h56ZCyclin-dependent kinase 22.7.11.220.526
3r8lZ30Cyclin-dependent kinase 22.7.11.220.523
3r7yZ04Cyclin-dependent kinase 22.7.11.220.520
3rak03ZCyclin-dependent kinase 22.7.11.220.516
1v1k3FPCyclin-dependent kinase 22.7.11.220.512
1w8cN69Cyclin-dependent kinase 22.7.11.220.512
2c6o4SPCyclin-dependent kinase 22.7.11.220.511
1pxmCK5Cyclin-dependent kinase 22.7.11.220.510
1w0xOLOCyclin-dependent kinase 22.7.11.220.510
3lfqA28Cyclin-dependent kinase 22.7.11.220.509
1y91CT9Cyclin-dependent kinase 22.7.11.220.508
2a0cCK9Cyclin-dependent kinase 22.7.11.220.505
4fkt48KCyclin-dependent kinase 22.7.11.220.504
1ke5LS1Cyclin-dependent kinase 22.7.11.220.502
1g5sI17Cyclin-dependent kinase 22.7.11.220.501
1oitHDTCyclin-dependent kinase 22.7.11.220.501
3r7uX96Cyclin-dependent kinase 22.7.11.220.501
2c6lDT4Cyclin-dependent kinase 22.7.11.220.492
2vttLZDCyclin-dependent kinase 22.7.11.220.492
4ek610KCyclin-dependent kinase 22.7.11.220.490
2a4lRRCCyclin-dependent kinase 22.7.11.220.488
2vthLZ2Cyclin-dependent kinase 22.7.11.220.486
3ezvEZVCyclin-dependent kinase 22.7.11.220.486
4fkg4CKCyclin-dependent kinase 22.7.11.220.486
4fkpLS5Cyclin-dependent kinase 22.7.11.220.485
3r7vZ02Cyclin-dependent kinase 22.7.11.220.484
1gii1PUCyclin-dependent kinase 22.7.11.220.481
1p2a5BNCyclin-dependent kinase 22.7.11.220.481
2r3jSCJCyclin-dependent kinase 22.7.11.220.481
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.481
3qwjX6ACyclin-dependent kinase 22.7.11.220.481
3rk708ZCyclin-dependent kinase 22.7.11.220.481
3qzgX67Cyclin-dependent kinase 22.7.11.220.479
3rkb12ZCyclin-dependent kinase 22.7.11.220.479
4fkv61KCyclin-dependent kinase 22.7.11.220.478
1pxlCK4Cyclin-dependent kinase 22.7.11.220.477
1ykr628Cyclin-dependent kinase 22.7.11.220.477
3s2pPMUCyclin-dependent kinase 22.7.11.220.477
2uznC96Cyclin-dependent kinase 22.7.11.220.474
2vv9IM9Cyclin-dependent kinase 22.7.11.220.474
3r83Z14Cyclin-dependent kinase 22.7.11.220.472
4fkj11KCyclin-dependent kinase 22.7.11.220.472
3rpo24ZCyclin-dependent kinase 22.7.11.220.471
3qqlX03Cyclin-dependent kinase 22.7.11.220.470
4ek816KCyclin-dependent kinase 22.7.11.220.470
2b52D42Cyclin-dependent kinase 22.7.11.220.469
3lfsA07Cyclin-dependent kinase 22.7.11.220.469
3qtxX43Cyclin-dependent kinase 22.7.11.220.469
4fkq42KCyclin-dependent kinase 22.7.11.220.469
2r3mSCXCyclin-dependent kinase 22.7.11.220.468
2xmyCDKCyclin-dependent kinase 22.7.11.220.468
3qxpX64Cyclin-dependent kinase 22.7.11.220.468
2w05FRTCyclin-dependent kinase 22.7.11.220.467
3sw418KCyclin-dependent kinase 22.7.11.220.467
2r3kSCQCyclin-dependent kinase 22.7.11.220.466
3rjc06ZCyclin-dependent kinase 22.7.11.220.466
4acm7YGCyclin-dependent kinase 22.7.11.220.465
3iggEFQCyclin-dependent kinase 22.7.11.220.464
3rni21ZCyclin-dependent kinase 22.7.11.220.464
2r3lSCWCyclin-dependent kinase 22.7.11.220.463
2exmZIPCyclin-dependent kinase 22.7.11.220.461
3qxoX65Cyclin-dependent kinase 22.7.11.220.461
1urwI1PCyclin-dependent kinase 22.7.11.220.459
2b53D23Cyclin-dependent kinase 22.7.11.220.459
2j9mPY8Cyclin-dependent kinase 22.7.11.220.459
3qtuX44Cyclin-dependent kinase 22.7.11.220.459
4fklCK2Cyclin-dependent kinase 22.7.11.220.458
4nj32KDCyclin-dependent kinase 22.7.11.220.457
1oirHDYCyclin-dependent kinase 22.7.11.220.456
1ke7LS3Cyclin-dependent kinase 22.7.11.220.455
3r7iX9ICyclin-dependent kinase 22.7.11.220.455
1b38ATPCyclin-dependent kinase 22.7.11.220.454
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.454
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.453
3rpy27ZCyclin-dependent kinase 22.7.11.220.452
3ezrEZRCyclin-dependent kinase 22.7.11.220.451
2w1hL0FCyclin-dependent kinase 22.7.11.220.450
3rmf20ZCyclin-dependent kinase 22.7.11.220.450
3wblPDYCyclin-dependent kinase 22.7.11.220.450
2bheBRYCyclin-dependent kinase 22.7.11.220.449
3sw719KCyclin-dependent kinase 22.7.11.220.449
2uzoC62Cyclin-dependent kinase 22.7.11.220.448
3fz1B98Cyclin-dependent kinase 22.7.11.220.448
3rpv26ZCyclin-dependent kinase 22.7.11.220.448
1aq1STUCyclin-dependent kinase 22.7.11.220.447
1hckATPCyclin-dependent kinase 22.7.11.220.447
2w06FRVCyclin-dependent kinase 22.7.11.220.447
3rm618ZCyclin-dependent kinase 22.7.11.220.446
3r8vZ62Cyclin-dependent kinase 22.7.11.220.443
2vtrLZBCyclin-dependent kinase 22.7.11.220.442
3r71X86Cyclin-dependent kinase 22.7.11.220.442
3qqhX0ACyclin-dependent kinase 22.7.11.220.441
4lyn1YGCyclin-dependent kinase 22.7.11.220.441
1b39ATPCyclin-dependent kinase 22.7.11.220.440
3rk909ZCyclin-dependent kinase 22.7.11.220.440
3sqq99ZCyclin-dependent kinase 22.7.11.220.440
4fks46KCyclin-dependent kinase 22.7.11.220.440