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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gr1FADFerredoxin--NADP reductase1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gr1FADFerredoxin--NADP reductase1.18.1.21.000
1e62FADFerredoxin--NADP reductase1.18.1.20.726
1h42FADFerredoxin--NADP reductase1.18.1.20.717
1ogiFADFerredoxin--NADP reductase1.18.1.20.706
3zbtFADFerredoxin--NADP reductase1.18.1.20.689
1queFADFerredoxin--NADP reductase1.18.1.20.657
1ogjFADFerredoxin--NADP reductase1.18.1.20.647
1w35FADFerredoxin--NADP reductase1.18.1.20.645
1e63FADFerredoxin--NADP reductase1.18.1.20.628
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.627
1e64FADFerredoxin--NADP reductase1.18.1.20.621
1h85FADFerredoxin--NADP reductase1.18.1.20.613
1qgzFADFerredoxin--NADP reductase1.18.1.20.611
1qh0FADFerredoxin--NADP reductase1.18.1.20.609
1bjkFADFerredoxin--NADP reductase1.18.1.20.604
4c43FADFerredoxin--NADP reductase1.18.1.20.604
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.597
1qgyFADFerredoxin--NADP reductase1.18.1.20.595
3zc3FADFerredoxin--NADP reductase1.18.1.20.593
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.591
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.587
2b5oFADFerredoxin--NADP reductase1.18.1.20.586
3vo2FADFerredoxin--NADP reductase/0.585
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.585
1go2FADFerredoxin--NADP reductase1.18.1.20.571
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.565
1gjrFADFerredoxin--NADP reductase1.18.1.20.564
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.556
4bprFADFerredoxin--NADP reductase1.18.1.20.555
1b2rFADFerredoxin--NADP reductase1.18.1.20.554
1sm4FADFerredoxin--NADP reductase/0.551
2rc6FADFerredoxin--NADP reductase/0.551
3jqrFADFerredoxin--NADP reductase, apicoplast/0.547
1gaqFADFerredoxin/0.543
1gawFADFerredoxin/0.543
3w5uFADFerredoxin/0.543
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.538
1w87FADFerredoxin--NADP reductase1.18.1.20.521
3qftFADNADPH--cytochrome P450 reductase/0.516
2ok8FADFerredoxin--NADP reductase, apicoplast/0.509
3qfsFADNADPH--cytochrome P450 reductase/0.503
3fpkFADFerredoxin-NADP reductase/0.502
2vnjFADNADPH:ferredoxin reductase/0.491
5ah5LSSLeucine--tRNA ligase/0.486
4yaoFADNADPH--cytochrome P450 reductase/0.482
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.478
1ja1FADNADPH--cytochrome P450 reductase/0.476
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.476
3qfcFADNADPH--cytochrome P450 reductase/0.475
3rsv3RSBeta-secretase 13.4.23.460.475
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.475
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.474
1ex75GPGuanylate kinase2.7.4.80.471
1amoFADNADPH--cytochrome P450 reductase/0.469
1yw8A75Methionine aminopeptidase 2/0.467
2hk9NAPShikimate dehydrogenase (NADP(+))/0.467
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.466
1r5hAO2Methionine aminopeptidase 2/0.464
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.464
2ea2F77Methionine aminopeptidase 2/0.463
4z87GDPInosine-5'-monophosphate dehydrogenase/0.461
2bpoFADNADPH--cytochrome P450 reductase/0.460
2x06NADL-sulfolactate dehydrogenase/0.459
4b66FADL-ornithine N(5)-monooxygenase/0.459
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.459
2wzySQXSoluble acetylcholine receptor/0.458
3af1GDPPantothenate kinase2.7.1.330.458
3opxU5PSuppressor of disruption of TFIIS/0.458
1obnASVIsopenicillin N synthase1.21.3.10.457
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.457
4j7hTRHPCZA361.3/0.457
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.456
4bfxZVXPantothenate kinase2.7.1.330.456
2vyqFADFerredoxin--NADP reductase1.18.1.20.455
4bfuZVUPantothenate kinase2.7.1.330.455
5a4vQUEGlutathione S-transferase F22.5.1.180.455
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.454
3rtnRTNBeta-secretase 13.4.23.460.454
1vceSAHDiphthine synthase/0.453
5dp2NAPCurF/0.453
2gjnFMNNitronate monooxygenase1.13.12.160.452
2z4y252Geranylgeranyl pyrophosphate synthase/0.452
4ba5PXGProbable aminotransferase/0.452
5a4wQCTGlutathione S-transferase F22.5.1.180.452
3ntrNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.451
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.451
4q0kGA3Phytohormone-binding protein/0.451
1a8pFADFerredoxin--NADP reductase/0.450
1r58AO5Methionine aminopeptidase 2/0.450
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2ejkSAHDiphthine synthase/0.450
2gevCOKPantothenate kinase2.7.1.330.450
3bnkFMNFlavoredoxin/0.450
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.450
1e79ATPATP synthase subunit alpha, mitochondrial/0.449
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.449
1j9zFADNADPH--cytochrome P450 reductase/0.449
1z41FMNNADPH dehydrogenase/0.449
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.449
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.449
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.449
3p0fBAUUridine phosphorylase 22.4.2.30.449
4q7f3D1Uncharacterized protein/0.449
1po7TZDBenzoylformate decarboxylase4.1.1.70.448
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
2ptfFMNUncharacterized protein MTH_863/0.448
1u2rSO1Elongation factor 2/0.447
2rc5FADFerredoxin--NADP reductase/0.447
3dr7GPDGDP-perosamine synthase/0.447
4mprTPPBenzoylformate decarboxylase4.1.1.70.447
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.446
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.446
3h3qH13Collagen type IV alpha-3-binding protein/0.446
4fk8FADFerredoxin--NADP reductase/0.446
1e7qNAPGDP-L-fucose synthase/0.445
1qzyTDEMethionine aminopeptidase 2/0.445
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2e0nSAHPrecorrin-2 C20-methyltransferase/0.445
2ejzSAHDiphthine synthase/0.445
2gyuHI6Acetylcholinesterase3.1.1.70.445
2pb6SAHDiphthine synthase/0.445
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.445
4jtqNAPAldo-keto reductase family 1 member C2/0.445
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.445
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2dsgSAHDiphthine synthase/0.444
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.444
1bsvNDPGDP-L-fucose synthase/0.443
1j49NADD-lactate dehydrogenase1.1.1.280.443
1jumBERHTH-type transcriptional regulator QacR/0.443
1xddAAYIntegrin alpha-L/0.443
4e32DWNMethyltransferase/0.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2p6dSAHDiphthine synthase/0.442
3nt5NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.442
3otwCOAPhosphopantetheine adenylyltransferase/0.442
4bfvZVVPantothenate kinase2.7.1.330.442
4gg1TZDBenzoylformate decarboxylase4.1.1.70.442
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.441
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.441
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.440
3hl0NADMaleylacetate reductase/0.440
3iktNADRedox-sensing transcriptional repressor Rex/0.440
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3wqmB29Diterpene synthase3.1.7.80.440
4e2yJHZMethyltransferase/0.440
4u140HKMuscarinic acetylcholine receptor M3/0.440