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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1eouSMSCarbonic anhydrase 24.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1eouSMSCarbonic anhydrase 24.2.1.11.000
3m2yBE0Carbonic anhydrase 24.2.1.10.705
3oikWZBCarbonic anhydrase 24.2.1.10.624
3m5eJDRCarbonic anhydrase 24.2.1.10.607
3sbhE65Carbonic anhydrase 24.2.1.10.599
3sbiE90Carbonic anhydrase 24.2.1.10.599
2eu3FF3Carbonic anhydrase 24.2.1.10.596
3mnaDWHCarbonic anhydrase 24.2.1.10.592
1if6FBUCarbonic anhydrase 24.2.1.10.590
3ffpLC1Carbonic anhydrase 24.2.1.10.590
1oq5CELCarbonic anhydrase 24.2.1.10.589
4itp1GDCarbonic anhydrase 24.2.1.10.587
3mmfD9HCarbonic anhydrase 24.2.1.10.584
4kniE1ECarbonic anhydrase 24.2.1.10.582
1kwrSG2Carbonic anhydrase 24.2.1.10.580
1ttm667Carbonic anhydrase 24.2.1.10.568
2h15B19Carbonic anhydrase 24.2.1.10.567
4kap1QVCarbonic anhydrase 24.2.1.10.567
1if4FBSCarbonic anhydrase 24.2.1.10.566
3mzcS6ICarbonic anhydrase 24.2.1.10.563
1kwqSG1Carbonic anhydrase 24.2.1.10.562
1a42BZUCarbonic anhydrase 24.2.1.10.557
3eft3BSCarbonic anhydrase 24.2.1.10.557
1xpz4TZCarbonic anhydrase 24.2.1.10.556
1g52F2BCarbonic anhydrase 24.2.1.10.554
3n0nP9BCarbonic anhydrase 24.2.1.10.554
3qykIE2Carbonic anhydrase 24.2.1.10.552
3dbuD8WCarbonic anhydrase 24.2.1.10.551
4knjE1FCarbonic anhydrase 24.2.1.10.548
2powI7CCarbonic anhydrase 24.2.1.10.547
3s9tE49Carbonic anhydrase 24.2.1.10.547
4m2vBZ1Carbonic anhydrase 24.2.1.10.547
3mhcARZCarbonic anhydrase 24.2.1.10.546
1oknSTBCarbonic anhydrase 24.2.1.10.544
3mhoJ43Carbonic anhydrase 24.2.1.10.542
3s8xE59Carbonic anhydrase 24.2.1.10.542
4ilx1EZCarbonic anhydrase 24.2.1.10.542
1if7SBRCarbonic anhydrase 24.2.1.10.540
3dc3AZMCarbonic anhydrase 24.2.1.10.540
3igpDT7Carbonic anhydrase 24.2.1.10.537
4itoMPXCarbonic anhydrase 24.2.1.10.537
3v2jAZMCarbonic anhydrase 24.2.1.10.535
2weoFBWCarbonic anhydrase 24.2.1.10.529
3b4fTUOCarbonic anhydrase 24.2.1.10.529
3k2fNKXCarbonic anhydrase 24.2.1.10.528
3oy0OY0Carbonic anhydrase 24.2.1.10.527
2wehFB1Carbonic anhydrase 24.2.1.10.526
1bn4AL9Carbonic anhydrase 24.2.1.10.525
3nb5R21Carbonic anhydrase 24.2.1.10.525
1g45FSBCarbonic anhydrase 24.2.1.10.523
1g4jFFBCarbonic anhydrase 24.2.1.10.523
1oklMNSCarbonic anhydrase 24.2.1.10.523
3dd82C7Carbonic anhydrase 24.2.1.10.523
1cnwEG1Carbonic anhydrase 24.2.1.10.522
3dazMZMCarbonic anhydrase 24.2.1.10.522
3d8wD8WCarbonic anhydrase 24.2.1.10.520
3oyqOYQCarbonic anhydrase 24.2.1.10.520
3t85SG7Carbonic anhydrase 24.2.1.10.518
4k0tD9ZCarbonic anhydrase 24.2.1.10.517
3dd0EZLCarbonic anhydrase 24.2.1.10.515
3dccD9ZCarbonic anhydrase 24.2.1.10.514
1bn1AL5Carbonic anhydrase 24.2.1.10.511
1g54FFBCarbonic anhydrase 24.2.1.10.509
3p5lIT5Carbonic anhydrase 24.2.1.10.509
1bntAL2Carbonic anhydrase 24.2.1.10.508
1zsbAZMCarbonic anhydrase 24.2.1.10.508
3hkuTORCarbonic anhydrase 24.2.1.10.508
3dcsMZMCarbonic anhydrase 24.2.1.10.506
4mo82VQCarbonic anhydrase 24.2.1.10.506
1ydaAZMCarbonic anhydrase 24.2.1.10.505
1bnnAL1Carbonic anhydrase 24.2.1.10.504
1cnyEG3Carbonic anhydrase 24.2.1.10.503
4bf19FKCarbonic anhydrase 24.2.1.10.502
3myqE27Carbonic anhydrase 24.2.1.10.501
1bnvAL7Carbonic anhydrase 24.2.1.10.500
3dcwEZLCarbonic anhydrase 24.2.1.10.500
1i91INQCarbonic anhydrase 24.2.1.10.499
2wd2MS5Carbonic anhydrase 24.2.1.10.499
1g4oBSBCarbonic anhydrase 24.2.1.10.498
3t84SG6Carbonic anhydrase 24.2.1.10.497
1bnwTPDCarbonic anhydrase 24.2.1.10.496
3bl1BL1Carbonic anhydrase 24.2.1.10.495
1i8zINLCarbonic anhydrase 24.2.1.10.494
3mhiJ90Carbonic anhydrase 24.2.1.10.494
3mdzEZLCarbonic anhydrase 74.2.1.10.493
3po6DT9Carbonic anhydrase 24.2.1.10.491
3t82SG4Carbonic anhydrase 24.2.1.10.490
4pxxCHDCarbonic anhydrase 24.2.1.10.489
5fl49FKCarbonic anhydrase 94.2.1.10.488
4k0zMZMCarbonic anhydrase 24.2.1.10.487
4n16CHDCarbonic anhydrase 24.2.1.10.487
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.485
3rz8RZ8Carbonic anhydrase 24.2.1.10.485
1bnuAL3Carbonic anhydrase 24.2.1.10.482
2x7uWZACarbonic anhydrase 24.2.1.10.482
2wejFB2Carbonic anhydrase 24.2.1.10.481
3l14I7BCarbonic anhydrase 24.2.1.10.481
4bfvZVVPantothenate kinase2.7.1.330.480
1i9mINWCarbonic anhydrase 24.2.1.10.479
3ni5C1HCarbonic anhydrase 24.2.1.10.475
3n2pAYXCarbonic anhydrase 24.2.1.10.474
1i9nIOACarbonic anhydrase 24.2.1.10.470
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3fw3ETSCarbonic anhydrase 44.2.1.10.469
4kp5E1FCarbonic anhydrase 124.2.1.10.466
1okmSABCarbonic anhydrase 24.2.1.10.465
1i9qIOFCarbonic anhydrase 24.2.1.10.462
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.461
3h3r14HCollagen type IV alpha-3-binding protein/0.460
2h4nAZMCarbonic anhydrase 24.2.1.10.459
4x5sAZMCarbonic anhydrase (Carbonate dehydratase)/0.459
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3mhlJ71Carbonic anhydrase 24.2.1.10.457
1rneC60Renin3.4.23.150.456
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.455
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.453
1ivsVAAValine--tRNA ligase6.1.1.90.452
3d9zD9ZCarbonic anhydrase 24.2.1.10.451
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
2cekN8TAcetylcholinesterase3.1.1.70.450
3f7bAG5Carbonic anhydrase 44.2.1.10.450
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.449
1jd0AZMCarbonic anhydrase 124.2.1.10.448
1xe65FPPlasmepsin-23.4.23.390.448
2cy0NAPShikimate dehydrogenase (NADP(+))/0.448
2g1n1IGRenin3.4.23.150.448
3h3sH15Collagen type IV alpha-3-binding protein/0.448
3h3qH13Collagen type IV alpha-3-binding protein/0.447
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.447
1w34FADFerredoxin--NADP reductase1.18.1.20.446
4bfwZVWPantothenate kinase2.7.1.330.446
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2rqfJH3Hemolymph juvenile hormone binding protein/0.444
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.444
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.444
1cnfFADNitrate reductase [NADH]1.7.1.10.443
3bt9DEQHTH-type transcriptional regulator QacR/0.443
3iexGMPPurine nucleoside phosphorylase/0.443
3p62FMNPentaerythritol tetranitrate reductase/0.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
2q1qOSPCarbonic anhydrase 24.2.1.10.442
2vyqFADFerredoxin--NADP reductase1.18.1.20.442
1o9bNAIQuinate/shikimate dehydrogenase/0.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440