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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4yhjAN2G protein-coupled receptor kinase 42.7.11.16

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4yhjAN2G protein-coupled receptor kinase 42.7.11.161.000
4c3pACPAurora kinase A2.7.11.10.498
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.488
2yaaATPDeath-associated protein kinase 2/0.487
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.485
3c4zADPRhodopsin kinase/0.481
3c4xATPRhodopsin kinase/0.473
4l9i8PRRhodopsin kinase/0.472
4qnyANPMitogen activated protein kinase, putative/0.470
5dosATPAurora kinase A2.7.11.10.469
4qmlANPSerine/threonine-protein kinase 242.7.11.10.467
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
3c4wATPRhodopsin kinase/0.463
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.461
4fv6E57Mitogen-activated protein kinase 12.7.11.240.459
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
2j0lANPFocal adhesion kinase 12.7.10.20.452
1finATPCyclin-dependent kinase 22.7.11.220.451
3bu5ATPInsulin receptor2.7.10.10.449
4j99ACPFibroblast growth factor receptor 2/0.448
3lltANPProtein serine/threonine kinase-1/0.446
3t8oATPRhodopsin kinase/0.446
4xlvACPInsulin receptor2.7.10.10.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.444
1jklANPDeath-associated protein kinase 12.7.11.10.443
2cjmATPCyclin-dependent kinase 22.7.11.220.441
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.440