sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4qxp | 1YE | Stimulator of interferon genes protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 1.000 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.598 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.554 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.545 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.525 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.514 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.464 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3r96 | ACO | MccE protein | / | 0.459 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.458 | |
| 5cfp | C2E | Stimulator of interferon genes protein | / | 0.458 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.450 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.448 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.448 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.448 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.448 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.447 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.447 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.447 | |
| 4p63 | NAD | Probable deoxyhypusine synthase | 2.5.1.46 | 0.447 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.446 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 5cfl | C2E | Stimulator of interferon genes protein | / | 0.446 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.445 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 3r95 | ACO | MccE protein | / | 0.445 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.445 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.444 | |
| 4blr | UTP | NTPase P4 | / | 0.444 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.443 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.443 | |
| 3ieu | GDP | GTPase Era | / | 0.442 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.441 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.440 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.440 |