Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nu5NADPhosphonate dehydrogenase1.20.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nu5NADPhosphonate dehydrogenase1.20.1.11.000
4nu6NADPhosphonate dehydrogenase1.20.1.10.615
4e5mNAPPhosphonate dehydrogenase1.20.1.10.591
4e5nNADPhosphonate dehydrogenase1.20.1.10.579
4e5kNADPhosphonate dehydrogenase1.20.1.10.557
2dbzNAPGlyoxylate reductase1.1.1.260.525
2w2lNADD-mandelate dehydrogenase/0.515
1g4tFTPThiamine-phosphate synthase/0.510
2tpsTPSThiamine-phosphate synthase/0.509
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.495
2dbqNAPGlyoxylate reductase1.1.1.260.488
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.482
2eklNADD-3-phosphoglycerate dehydrogenase/0.477
2g5cNADPrephenate dehydrogenase/0.477
4z0pNDPNAD-dependent dehydrogenase/0.475
3sz0FADSulfide-quinone reductase/0.472
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.472
2hu2NADC-terminal binding protein 1/0.469
1g67TZPThiamine-phosphate synthase/0.468
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.467
2jn3JN3Fatty acid-binding protein, liver/0.467
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.467
3kpkFADSulfide-quinone reductase/0.467
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.466
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.465
3lpiZ74Beta-secretase 13.4.23.460.465
4mihFADPyranose 2-oxidase1.1.3.100.465
3ukoNADAlcohol dehydrogenase class-3/0.463
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.463
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.462
1g4sTPSThiamine-phosphate synthase/0.461
3t14FADSulfide-quinone reductase/0.461
2q4bNAPUncharacterized protein At5g02240/0.460
3t2zFADSulfide-quinone reductase/0.460
4weqNAPNAD-dependent dehydrogenase/0.460
1hkuNADC-terminal-binding protein 11.1.10.459
2y05NAPProstaglandin reductase 1/0.458
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.458
2znnS44Peroxisome proliferator-activated receptor alpha/0.457
5a3bAPRSIR2 family protein/0.457
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.457
3jynNDPQuinone oxidoreductase/0.456
4q72FADBifunctional protein PutA/0.456
5dbgNADIridoid synthase1.3.1.990.456
3t2kFADSulfide-quinone reductase/0.455
2dteNAIGlucose 1-dehydrogenase related protein/0.454
2hcdBIVVitamin D3 receptor A/0.454
3ggoNAIPrephenate dehydrogenase/0.454
4dplNAPMalonyl-CoA reductase1.2.1.750.454
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.454
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.453
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.453
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.452
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.452
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.452
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.452
1ipeNDPTropinone reductase 21.1.1.2360.451
2givACOHistone acetyltransferase KAT8/0.451
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.451
1g69TZPThiamine-phosphate synthase/0.450
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.450
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.450
4jlj1NMDeoxycytidine kinase2.7.1.740.450
5jlaNADPutative short-chain dehydrogenase/reductase/0.450
1x7gNAPPutative ketoacyl reductase1.3.10.449
1yb5NAPQuinone oxidoreductase1.6.5.50.449
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
2zb3NDPProstaglandin reductase 21.3.1.480.449
3ixj586Beta-secretase 13.4.23.460.449
3kb6NADD-lactate dehydrogenase/0.449
3gw9VNILanosterol 14-alpha-demethylase/0.448
4qe6JN3Bile acid receptor/0.448
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.447
2vbdV10Isopenicillin N synthase1.21.3.10.447
4xqcNADHomospermidine synthase2.5.1.440.447
5a3cNADSIR2 family protein/0.447
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3hz5Z64Heat shock protein HSP 90-alpha/0.446
3oqkS52Renin3.4.23.150.446
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.446
1me6IVSPlasmepsin-23.4.23.390.445
2npaMMBPeroxisome proliferator-activated receptor alpha/0.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
1mjbACOHistone acetyltransferase ESA1/0.444
1pr9NAPL-xylulose reductase1.1.1.100.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.444
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.444
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.444
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.444
3oibFDAPutative acyl-CoA dehydrogenase/0.444
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.444
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.443
1osvCHCBile acid receptor/0.443
2gjlFMNNitronate monooxygenase1.13.12.160.443
2jahNDPClavaldehyde dehydrogenase/0.443
3bg7FADPyranose 2-oxidase/0.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.443
4rpjFADUDP-galactopyranose mutase5.4.99.90.443
4xq9NADHomospermidine synthase2.5.1.440.443
5bqfNAPProbable hydroxyacid dehydrogenase protein/0.443
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
1ppjANYCytochrome b/0.442
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.442
4dpwAGSMevalonate diphosphate decarboxylase/0.442
4fd2ADPChaperone protein ClpB/0.442
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
5jscFADPutative acyl-CoA dehydrogenase/0.442
1h2bNAJNAD-dependent alcohol dehydrogenase/0.441
1qorNDPQuinone oxidoreductase 1/0.441
2fzwNADAlcohol dehydrogenase class-31.1.1.10.441
2qa2FADPolyketide oxygenase CabE/0.441
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.441
3ctyFADProbable thioredoxin reductase/0.441
3syiFADSulfide-quinone reductase/0.441
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4l4xNDPAmphI/0.441
4nmdFDABifunctional protein PutA/0.441
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.441
1hb3SCVIsopenicillin N synthase1.21.3.10.440
1xq6NAPUncharacterized protein At5g02240/0.440
2cduFADNADH oxidase/0.440
2ft9CHDFatty acid-binding protein 2, liver/0.440
3ohf3HFBeta-secretase 13.4.23.460.440
3uylTYDProbable NDP-rhamnosyltransferase/0.440
4b8wNAPGDP-L-fucose synthase1.1.1.2710.440
4l8u9AZSerum albumin/0.440
4ly91YYGlucokinase regulatory protein/0.440
4q73FADBifunctional protein PutA/0.440