sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.709 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.682 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.672 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.660 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.656 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.647 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.647 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.641 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.636 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.636 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.630 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.623 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.617 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.617 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.614 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.607 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.604 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.600 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.600 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.595 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.595 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.591 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.586 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.585 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.581 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.561 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.536 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.470 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.467 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.464 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.458 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.456 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.450 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1zdw | FLV | Prenyltransferase | / | 0.443 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.443 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 |