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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4iqgNAPShort-chain dehydrogenase/reductase SDR

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4iqgNAPShort-chain dehydrogenase/reductase SDR/1.000
4j7uNAPSepiapterin reductase1.1.1.1530.576
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.573
4bmvNAPShort-chain dehydrogenase/0.569
4hwkNAPSepiapterin reductase1.1.1.1530.564
4j7xNAPSepiapterin reductase1.1.1.1530.561
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.556
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.551
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.550
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.549
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.549
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.548
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.547
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.546
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.544
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.543
1ipeNDPTropinone reductase 21.1.1.2360.538
1ae1NAPTropinone reductase 1/0.536
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.536
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.536
1n5dNDPCarbonyl reductase [NADPH] 1/0.535
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.535
1oaaNAPSepiapterin reductase1.1.1.1530.532
2jahNDPClavaldehyde dehydrogenase/0.531
3d3wNAPL-xylulose reductase1.1.1.100.529
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.527
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.527
1pr9NAPL-xylulose reductase1.1.1.100.523
3w8eNAD3-hydroxybutyrate dehydrogenase/0.523
4yagNAIC alpha-dehydrogenase/0.521
5jlaNADPutative short-chain dehydrogenase/reductase/0.521
5idwNAPShort-chain dehydrogenase/reductase SDR/0.520
1snyNAPLD36273p/0.519
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.519
1x7gNAPPutative ketoacyl reductase1.3.10.518
2dteNAIGlucose 1-dehydrogenase related protein/0.518
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.517
4qecNAPElxO/0.517
1xg5NAPDehydrogenase/reductase SDR family member 11/0.516
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.515
4yaiNAIC alpha-dehydrogenase/0.515
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.514
4fn4NADShort chain dehydrogenase/0.514
3p19NDPPutative blue fluorescent protein/0.512
3toxNAPPutative oxidoreductase/0.511
4esoNAPPutative oxidoreductase/0.511
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.510
3gy0NAPNAD(P)-dependent oxidoreductase/0.510
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.509
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.509
1x7hNDPPutative ketoacyl reductase1.3.10.509
2bd0NAPSepiapterin reductase/0.507
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.506
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.506
1iy8NADLevodione reductase/0.505
1wntNAPL-xylulose reductase1.1.1.100.505
2yutNAPPutative short-chain oxidoreductase/0.505
3ai2NDPNADPH-sorbose reductase/0.505
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.504
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.504
3tn7NJPShort-chain alcohol dehydrogenase/0.504
4dc1NDPPutative ketoacyl reductase1.3.10.504
3vdqNAD3-hydroxybutyrate dehydrogenase/0.503
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.501
2yy7NADL-threonine dehydrogenase/0.497
3s55NADPutative short-chain dehydrogenase/reductase/0.497
3uceNDPDehydrogenase/0.497
3wdsNADNADH-dependent quinuclidinone reductase/0.497
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.497
3l77NJPShort-chain alcohol dehydrogenase/0.496
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.495
3sjuNDPKeto reductase/0.494
3w8fNAD3-hydroxybutyrate dehydrogenase/0.494
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.493
3qrwNDPPutative ketoacyl reductase1.3.10.493
5ig2NADShort-chain dehydrogenase/reductase SDR/0.493
1rwbNADGlucose 1-dehydrogenase1.1.1.470.492
3ak4NADNADH-dependent quinuclidinone reductase/0.492
4b79NADProbable short-chain dehydrogenase/0.492
4gh5NADShort-chain dehydrogenase/reductase SDR/0.492
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.491
5jydNADShort chain dehydrogenase/0.491
1w4zNAPPutative ketoacyl reductase1.3.10.490
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.490
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.488
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.485
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.485
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.484
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.482
3ai3NDPNADPH-sorbose reductase/0.480
3u4cNDPNADPH-dependent reductase BacG/0.479
1xkqNDPUncharacterized protein/0.477
3w8dNAD3-hydroxybutyrate dehydrogenase/0.476
1g6kNADGlucose 1-dehydrogenase1.1.1.470.475
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.475
2wdzNADGalactitol dehydrogenase/0.475
1geeNADGlucose 1-dehydrogenase1.1.1.470.474
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.473
2wsbNADGalactitol dehydrogenase/0.473
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.472
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.472
5lc1NADL-threonine 3-dehydrogenase/0.472
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.471
3rj9NADAlcohol dehydrogenase1.1.1.10.471
3sx2NADUncharacterized protein/0.470
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.469
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.469
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.468
1sbyNADAlcohol dehydrogenase1.1.1.10.468
5emhNAPIridoid synthase1.3.1.990.463
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.462
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.462
1zemNADXylitol dehydrogenase/0.461
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.461
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.460
2p5uNADUDP-glucose 4-epimerase/0.459
3rj5NADAlcohol dehydrogenase1.1.1.10.459
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.459
1gcoNADGlucose 1-dehydrogenase1.1.1.470.458
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.458
3lqfNADGalactitol dehydrogenase/0.458
4qedNAPElxO/0.458
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.457
1nytNAPShikimate dehydrogenase (NADP(+))/0.455
3a4vNADNDP-sugar epimerase/0.455
1t2aNDPGDP-mannose 4,6 dehydratase4.2.1.470.453
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.453
4b8wNAPGDP-L-fucose synthase1.1.1.2710.453
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.452
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.452
4nbwNADShort-chain dehydrogenase/reductase SDR/0.452
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
1n7gNDPGDP-mannose 4,6 dehydratase 24.2.1.470.449
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.449
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.449
4jbiNDPAlcohol dehydrogenase (Zinc)/0.448
1b14NADAlcohol dehydrogenase1.1.1.10.447
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.447
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.446
5jy1NADPutative short-chain dehydrogenase/reductase/0.446
1yqdNAPSinapyl alcohol dehydrogenase/0.445
3f1kNAPUncharacterized oxidoreductase YciK10.445
3r3sNADPutative oxidoreductase/0.445
1mg5NAIAlcohol dehydrogenase1.1.1.10.444
1i3lNADUDP-glucose 4-epimerase/0.443
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3tscNADUncharacterized protein/0.440