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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hmhF94Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hmhF94Tankyrase-22.4.2.301.000
4iueAJ4Tankyrase-22.4.2.300.668
4l10A63Tankyrase-22.4.2.300.650
4hl515WTankyrase-22.4.2.300.643
4hlf15ZTankyrase-22.4.2.300.641
4l0t1V0Tankyrase-22.4.2.300.635
4kzl20DTankyrase-22.4.2.300.634
4bufF36Tankyrase-22.4.2.300.633
4hlh20DTankyrase-22.4.2.300.632
4l0i1UWTankyrase-22.4.2.300.632
4bueJQFTankyrase-22.4.2.300.631
4l321VFTankyrase-22.4.2.300.626
4hlm16STankyrase-22.4.2.300.624
3kr8XAVTankyrase-22.4.2.300.623
4l2f1V3Tankyrase-22.4.2.300.623
4l33F70Tankyrase-22.4.2.300.620
4bus32FTankyrase-22.4.2.300.619
4buxF35Tankyrase-22.4.2.300.617
4hknLU2Tankyrase-22.4.2.300.614
4hkkAGITankyrase-22.4.2.300.612
5aku29FTankyrase-22.4.2.300.612
4l0v1V1Tankyrase-22.4.2.300.610
4l341VGTankyrase-22.4.2.300.610
4l31F08Tankyrase-22.4.2.300.608
4buuF38Tankyrase-22.4.2.300.606
4l2k1V8Tankyrase-22.4.2.300.606
4l2g1V4Tankyrase-22.4.2.300.602
4bu908CTankyrase-22.4.2.300.600
4l0s1UZTankyrase-22.4.2.300.598
4j22AJ7Tankyrase-22.4.2.300.597
4bs4A64Tankyrase-22.4.2.300.595
4hlk431Tankyrase-22.4.2.300.595
4l091URTankyrase-22.4.2.300.595
4buwF33Tankyrase-22.4.2.300.591
4kzuA73Tankyrase-22.4.2.300.591
4krs1SXTankyrase-12.4.2.300.585
4buiW2ETankyrase-22.4.2.300.584
3p0pNNFTankyrase-22.4.2.300.583
4but31FTankyrase-22.4.2.300.583
4bud29FTankyrase-22.4.2.300.582
4j3lAJ5Tankyrase-22.4.2.300.582
4hlg20BTankyrase-22.4.2.300.572
4j3mAJ8Tankyrase-22.4.2.300.568
4j21AJ6Tankyrase-22.4.2.300.566
4pnrG18Tankyrase-22.4.2.300.565
4avwG18Tankyrase-22.4.2.300.564
4hkiFLNTankyrase-22.4.2.300.558
4buv16ITankyrase-22.4.2.300.544
4bjbP34Tankyrase-22.4.2.300.538
4msk2C8Tankyrase-12.4.2.300.517
4avuLDRTankyrase-22.4.2.300.512
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.482
4pnmNU1Tankyrase-22.4.2.300.482
1lnmDTXBilin-binding protein/0.481
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
1c7oPPGHemolysin/0.468
4bjcRPBTankyrase-22.4.2.300.468
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
4tjy3GNTankyrase-22.4.2.300.467
4dvi2IWTankyrase-12.4.2.300.466
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.465
3v94WYQPhosphodiesterase/0.463
2ejzSAHDiphthine synthase/0.461
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.461
1sweBTNStreptavidin/0.460
4i9i1DYTankyrase-12.4.2.300.459
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.458
3ghvGHCDihydrofolate reductase1.5.1.30.458
4gbrCAUBeta-2 adrenergic receptor/0.458
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.454
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.453
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.452
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.452
1bk0ACVIsopenicillin N synthase1.21.3.10.450
1jtqLY3Thymidylate synthase/0.450
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.450
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.450
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.450
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
3rsv3RSBeta-secretase 13.4.23.460.450
3zkyWT4Isopenicillin N synthase1.21.3.10.449
1obnASVIsopenicillin N synthase1.21.3.10.448
1rkwPNTHTH-type transcriptional regulator QacR/0.448
3ekuCY9Actin-5C/0.448
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3h4vDVPPteridine reductase 11.5.1.330.448
4jlk1NODeoxycytidine kinase2.7.1.740.448
1pqc444Oxysterols receptor LXR-beta/0.447
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.447
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.447
4ggzBTNBll1558 protein/0.447
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3ghwGHWDihydrofolate reductase1.5.1.30.446
3imxB84Glucokinase2.7.1.20.446
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.446
3tnfGNPRas-related protein Rab-8A/0.446
1fvpFMANon-fluorescent flavoprotein/0.445
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3jynNDPQuinone oxidoreductase/0.445
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.444
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4b2gV1NUncharacterized protein/0.444
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2iviACWIsopenicillin N synthase1.21.3.10.443
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4kxjP34Nucleoprotein/0.443
1xf0ASDAldo-keto reductase family 1 member C3/0.442
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.442
4nbjD3YD-tyrosyl-tRNA(Tyr) deacylase/0.442
2rh1CAUBeta-2 adrenergic receptor/0.442
5jqhCAUBeta-2 adrenergic receptor/0.442
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1ygkRRCPyridoxal kinase2.7.1.350.441
2zscBTNTamavidin2/0.441
3h59H59Genome polyprotein2.7.7.480.441
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.441
4li71XPTankyrase-12.4.2.300.441
4bj9UHBTankyrase-22.4.2.300.440