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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4g160VMCasein kinase I isoform gamma-32.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4g160VMCasein kinase I isoform gamma-32.7.11.11.000
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.786
4g170VNCasein kinase I isoform gamma-32.7.11.10.700
2izrBRKCasein kinase I isoform gamma-32.7.11.10.636
2chlDKICasein kinase I isoform gamma-32.7.11.10.553
2izt23DCasein kinase I isoform gamma-32.7.11.10.534
4hgs15GCasein kinase I isoform gamma-32.7.11.10.520
2izsBRQCasein kinase I isoform gamma-32.7.11.10.512
1eh4IC1Casein kinase I homolog 12.7.11.10.510
2c475IDCasein kinase I isoform gamma-2/0.489
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.484
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.479
4wboANWRhodopsin kinase/0.479
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.478
2izuP01Casein kinase I isoform gamma-32.7.11.10.478
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.477
1gij2PUCyclin-dependent kinase 22.7.11.220.475
4hgt15GCasein kinase I isoform delta2.7.11.10.472
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.469
3mtfA3FActivin receptor type-12.7.11.300.469
4i22IREEpidermal growth factor receptor2.7.10.10.469
2xikJ60Serine/threonine-protein kinase 252.7.11.10.468
4bgg844Activin receptor type-12.7.11.300.468
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.468
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.468
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.467
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4hnf16WCasein kinase I isoform delta2.7.11.10.466
3bc3OPTCathepsin L13.4.22.150.465
4tuvCPZCytochrome P450 1191.140.465
5e8wSTUTGF-beta receptor type-12.7.11.300.465
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.464
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1k6cMK1Gag-Pol polyprotein3.4.23.160.463
4ic7ANPMitogen-activated protein kinase 72.7.11.240.463
1di8DTQCyclin-dependent kinase 22.7.11.220.462
1u54ACPActivated CDC42 kinase 1/0.462
1xl2189Gag-Pol polyprotein3.4.23.160.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.462
2wotZZGTGF-beta receptor type-12.7.11.300.461
3hl7I47Mitogen-activated protein kinase 14/0.461
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.459
3uyt0CKCasein kinase I isoform delta2.7.11.10.459
4kbk1QGCasein kinase I isoform delta2.7.11.10.459
2uxhQUEHTH-type transcriptional regulator TtgR/0.458
5cnoANPEpidermal growth factor receptor2.7.10.10.458
1gih1PUCyclin-dependent kinase 22.7.11.220.457
1h1s4SPCyclin-dependent kinase 22.7.11.220.457
1oiyN41Cyclin-dependent kinase 22.7.11.220.456
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.456
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4kb81QNCasein kinase I isoform delta2.7.11.10.456
3uzp0CKCasein kinase I isoform delta2.7.11.10.455
3zewSTUEphrin type-B receptor 42.7.10.10.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
4c4jX21Dual specificity protein kinase TTK2.7.12.10.454
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.451
4iaq2GM5-hydroxytryptamine receptor 1B/0.451
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.451
4qgiROCGag-Pol polyprotein3.4.23.160.451
1xjdSTUProtein kinase C theta type2.7.11.130.450
2iw94SPCyclin-dependent kinase 22.7.11.220.450
2q54MU1Protease/0.450
2uxpCLMHTH-type transcriptional regulator TtgR/0.450
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3c4zADPRhodopsin kinase/0.450
4kb81QOCasein kinase I isoform delta2.7.11.10.450
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1pkdUCNCyclin-dependent kinase 22.7.11.220.449
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.449
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.449
3il1B5DGlutamate receptor 2/0.449
1idb0DOGag-Pol polyprotein/0.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2uxuNARHTH-type transcriptional regulator TtgR/0.448
3nwxKVSGag-Pol polyprotein3.4.23.160.448
1q1wFADPutidaredoxin reductase1.18.1.50.447
2btsU32Cyclin-dependent kinase 22.7.11.220.447
2itqITQEpidermal growth factor receptor2.7.10.10.447
2iw84SPCyclin-dependent kinase 22.7.11.220.447
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.447
3c50ADPRhodopsin kinase/0.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3kf7L9GMitogen-activated protein kinase 14/0.447
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.447
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.446
4hdfG52Gag-Pol polyprotein3.4.23.160.446
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.446
4xumIMNPeroxisome proliferator-activated receptor gamma/0.446
1me7MOAInosine-5'-monophosphate dehydrogenase/0.445
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.445
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.445
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.445
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
4qmpDKISerine/threonine-protein kinase 242.7.11.10.445
1a8g2Z4Gag-Pol polyprotein3.4.23.160.444
1j39UPGDNA beta-glucosyltransferase/0.444
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.444
2xa4AZ5Tyrosine-protein kinase JAK2/0.444
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.443
2of2547Tyrosine-protein kinase Lck2.7.10.20.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
3umw596Serine/threonine-protein kinase pim-12.7.11.10.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.443
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.443
1csnATPCasein kinase I homolog 12.7.11.10.442
1hvsA77Gag-Pol polyprotein/0.442
1ndzFR5Adenosine deaminase3.5.4.40.442
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
1rfuADPPyridoxal kinase2.7.1.350.442
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3ekp478Gag-Pol polyprotein3.4.23.160.442
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.442
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
2ckeIQUDeath-associated protein kinase 2/0.441
2pvnP63Casein kinase II subunit alpha2.7.11.10.441
2vn0TDZCytochrome P450 2C8/0.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
3o9iA61Gag-Pol polyprotein/0.441
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4f630S7Fibroblast growth factor receptor 1/0.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
4r21STRCytochrome P450 family 17 polypeptide 2/0.441
2hw1ANPKetohexokinase/0.440
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
3qa2XNAKetohexokinase/0.440
3u8w09JMitogen-activated protein kinase 14/0.440
4xhgADPUncharacterized protein/0.440